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公开(公告)号:US20060199802A1
公开(公告)日:2006-09-07
申请号:US10566193
申请日:2004-07-29
申请人: Melwyn Abreo , Daniel Harvey , Heins Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael Winther , Vishnumurthy Kodumuru , Cindy Hudson , Mikhail Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人: Melwyn Abreo , Daniel Harvey , Heins Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael Winther , Vishnumurthy Kodumuru , Cindy Hudson , Mikhail Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号: A61K31/551 , A61K31/496
CPC分类号: C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要: Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (1): wherein: W is —O—, —N(R1)—, C(O), S(O)t ; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1) , C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R1)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译: 公开了在哺乳动物,优选人中治疗SCD介导的疾病或病症的方法,其中所述方法包括向有需要的哺乳动物施用式(1)化合物:其中:W是-O - , - N (R 1) - ,C(O),S(O)t; (其中t为0,1或2),N(R1)S(O)2,S(O)2N(R1),C(O)N(R1)或N(R1)C(O) ); 并且V是C(O),C(S),C(O)N(R 1) - ,C(O)O-,S(O)2 - ,S(O)2 N(R 1) - 或C )H; 并且x,y,R1,R2,R3,R4,R5,R6,R7,R7a,R8,R8a,R9,R9a,R10和R10a在本文中定义。 还公开了包含式(I)化合物的药物组合物。