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公开(公告)号：US20080248096A1
公开(公告)日：2008-10-09
申请号：US12020378
申请日：2008-01-25
IPC分类号： A61K9/127 , A61K31/4375 , A61P35/00
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/127 , A61K9/19 , A61K31/4745
摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.
摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。
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公开(公告)号：US07348025B2
公开(公告)日：2008-03-25
申请号：US10663573
申请日：2003-09-16
IPC分类号： A61K31/4745 , A61K9/127 , A61L9/04
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/127 , A61K9/19 , A61K31/4745
摘要： Provided herein is a method of treating primary lung cancer or metastatic cancer to the lung in an individual by delivering at least once to the respiratory tract of the individual via inhalation a nebulized liposomal aerosol comprising a dilauroylphosphatidylcholine liposome containing camptothecin or a derivative thereof in an amount sufficient to deliver a pharmacologically effective dose of the camptothecin or its derivative to treat the cancer. Also provided is a nebulized liposomal aerosol comprising the DLPC containing the camptothecin or its derivative and a method of making the liposome-drug comprising the aerosol.
摘要翻译： 本文提供了一种通过吸入至少一次向个体的呼吸道递送一次雾化的脂质体气雾剂，其包含含有喜树碱或其衍生物的二月桂酰磷脂酰胆碱脂质体，其量为一种治疗个体的原发性肺癌或转移性癌症的方法 足以提供药理学有效剂量的喜树碱或其衍生物以治疗癌症。 还提供了包含含有喜树碱或其衍生物的DLPC的雾化脂质体气雾剂和制备包含气溶胶的脂质体药物的方法。
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