公开(公告)号：US20200377561A1

公开(公告)日：2020-12-03

申请号：US16616372

申请日：2018-05-23

Applicant: Robert S. HODGES ,  Ziqing JIANG ,  Lajos GERA ,  Colin T. MANT ,  THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate

Inventor： Robert S. HODGES ,  Ziqing JIANG ,  Lajos GERA ,  Colin T. MANT

IPC: C07K14/46 ,  A61K38/00 ,  A61P31/04

Abstract: Antimicrobial agents, including antimicrobial peptides (AMPs) and uses thereof. Compositions and methods of using dermaseptin-type and piscidin-type antimicrobial peptide variants that demonstrate activity and improved therapeutic indices against microbial pathogens. The peptide compositions demonstrate the ability to not only maintain or improve antimicrobial activity against bacterial pathogens including Gram-negative microorganisms Acinetobacter baumannii and Pseudomonas aeruginosa, but also significantly decrease hemolytic activity against human red blood cells. Specificity determinants within the AMPs change selectivity from broad spectrum antimicrobial activity to Gram-negative selectivity.