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公开(公告)号：US11110074B2
公开(公告)日：2021-09-07
申请号：US16876492
申请日：2020-05-18
发明人： Cara Baron Casseday , Elizabeth Ludington , Michael Skinner , Susan E. Dubé , Roberta L. Rogowski , Philip Jochelson , Robert Mansbach
IPC分类号： A61K31/335 , A61K31/55
摘要： Methods of improving the pharmacokinetics of doxepin in a patient.
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公开(公告)号：US20210283094A1
公开(公告)日：2021-09-16
申请号：US17328141
申请日：2021-05-24
IPC分类号： A61K31/335 , A61K31/4535 , A61K31/4162 , A61K31/4985 , A61K31/505 , A61K31/343 , A61K31/437 , A61P25/00 , A61P25/20
摘要： A composition comprising doxepin, or a pharmaceutically acceptable salt, or prodrug thereof, and a compound that enhances sleep onset, sleep maintenance or reduces early morning awakenings. These compositions are useful for treating multiple manifestations of insomnia.
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公开(公告)号：US20220110908A1
公开(公告)日：2022-04-14
申请号：US17408945
申请日：2021-08-23
发明人： Luigi Schioppi , Brian Talmadge Dorsey , Michael Skinner , John Carter , Robert Mansbach , Philip Jochelson , Roberta L. Rogowski , Cara Baron Casseday , Meredith Perry , Bryan Knox
IPC分类号： A61K31/335 , A61K9/28 , A61K9/20 , A61K47/38 , A61K47/02
摘要： The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
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4.发明授权公开(公告)号：US10758510B2
公开(公告)日：2020-09-01
申请号：US16377731
申请日：2019-04-08
发明人： Susan E. Dubé , Neil B. Kavey
IPC分类号： A61K31/335
摘要： The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
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公开(公告)号：US10653662B2
公开(公告)日：2020-05-19
申请号：US16363128
申请日：2019-03-25
IPC分类号： A61K31/335
摘要： Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
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公开(公告)号：US20210393567A1
公开(公告)日：2021-12-23
申请号：US17467360
申请日：2021-09-06
发明人： Cara Baron Casseday , Elizabeth Ludington , Michael Skinner , Susan E. Dubé , Roberta L. Rogowski , Philip Jochelson , Robert Mansbach
IPC分类号： A61K31/335 , A61K31/55
摘要： Methods of improving the pharmacokinetics of doxepin in a patient.
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公开(公告)号：US20200170991A1
公开(公告)日：2020-06-04
申请号：US16779901
申请日：2020-02-03
发明人： Luigi Schioppi , Brian Talmadge Dorsey , Michael Skinner , John Carter , Robert Mansbach , Philip Jochelson , Roberta L. Rogowski , Cara Baron Casseday , Meredith Perry , Bryan Knox
IPC分类号： A61K31/335 , A61K9/20 , A61K9/28 , A61K47/02 , A61K47/38
摘要： The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
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公开(公告)号：US12083090B2
公开(公告)日：2024-09-10
申请号：US16876446
申请日：2020-05-18
IPC分类号： A61K31/335 , A61P25/20
CPC分类号： A61K31/335
摘要： Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
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公开(公告)号：US20220151975A1
公开(公告)日：2022-05-19
申请号：US17588975
申请日：2022-01-31
IPC分类号： A61K31/335
摘要： Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe for elderly individuals.
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公开(公告)号：US11096920B2
公开(公告)日：2021-08-24
申请号：US16779901
申请日：2020-02-03
发明人： Luigi Schioppi , Brian Talmadge Dorsey , Michael Skinner , John Carter , Robert Mansbach , Philip Jochelson , Roberta L. Rogowski , Cara Baron Casseday , Meredith Perry , Bryan Knox
IPC分类号： A61K31/335 , A61K9/20 , A61K9/28 , A61K47/02 , A61K47/38
摘要： The invention disclosed herein generally relates to low-dose oral doxepin pharmaceutical formulations and the use of these formulations to promote sleep.
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