摘要:
(R)—N-benzyl-2-(benzyloxycarbonylamino)-3-methoxypropionamide is an intermediate useful for preparing lacosamide. It can be prepared, for example, by combining (R)—N-benzyl-2-(benzyloxycarbonylamino)-3-hydroxypropionamide with dimethylsulfate, followed by mixing with an alkali or alkaline earth metal hydroxide at a temperature of about 25° C. to about −15° C.