公开(公告)号：US08980871B2

公开(公告)日：2015-03-17

申请号：US12678539

申请日：2008-09-19

申请人： Daniel B. Kim-Shapiro ,  S. Bruce King ,  Daniel A. Sweeney ,  Mark T. Gladwin

发明人： Daniel B. Kim-Shapiro ,  S. Bruce King ,  Daniel A. Sweeney ,  Mark T. Gladwin

IPC分类号： A61K31/33 ,  A01N43/00 ,  A61K31/58

CPC分类号： A61K31/58 ,  Y02A50/411

摘要： Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds preferentially react with cell-free OxyHb, as compared to OxyHb encapsulated in a red blood cell, and reacts with MetHb to form iron-nitrosyl Hb or nitrite bound MetHb. It has also been found that such compounds reduce cell-free Hb and hemolysis. Active compounds are also contemplated for use in combination therapies, for example, in combination with the administration of red blood cells and/or an agent that promotes hematopoiesis, or in combination with the administration of a nitric oxide donor.

摘要翻译： 本文提供了通过施用足以治疗所述溶血的量的活性化合物来治疗溶血的方法。 已经发现，与包封在红细胞中的OxyHb相比，硝酰基供体或类似化合物优先与无细胞的OxyHb反应，并与MetHb反应形成亚硝酰基Hb或亚硝酸盐结合的MetHb。 还已经发现，这些化合物减少无细胞的Hb和溶血。 还考虑活性化合物用于组合疗​​法，例如与施用红细胞和/或促进造血作用的药剂组合，或与施用一氧化氮供体组合使用。

公开(公告)号：US20100239692A1

公开(公告)日：2010-09-23

申请号：US12678539

申请日：2008-09-19

申请人： Daniel B. Kim-Shapiro ,  S. Bruce King ,  Daniel A. Sweeney ,  Mark T. Gladwin

发明人： Daniel B. Kim-Shapiro ,  S. Bruce King ,  Daniel A. Sweeney ,  Mark T. Gladwin

IPC分类号： A61K33/00 ,  A61K31/185 ,  A61P7/04

CPC分类号： A61K31/58 ,  Y02A50/411

摘要： Provided herein are methods of treating hemolysis by administering an active compound in an amount sufficient to treat said hemolysis. It has been found that nitroxyl donors or similar compounds preferentially react with cell-free OxyHb, as compared to OxyHb encapsulated in a red blood cell, and reacts with MetHb to form iron-nitrosyl Hb or nitrite bound MetHb. It has also been found that such compounds reduce cell-free Hb and hemolysis. Active compounds are also contemplated for use in combination therapies, for example, in combination with the administration of red blood cells and/or an agent that promotes hematopoiesis, or in combination with the administration of a nitric oxide donor.

摘要翻译： 本文提供了通过施用足以治疗所述溶血的量的活性化合物来治疗溶血的方法。 已经发现，与包封在红细胞中的OxyHb相比，硝酰基供体或类似化合物优先与无细胞的OxyHb反应，并与MetHb反应形成亚硝酰基Hb或亚硝酸盐结合的MetHb。 还已经发现，这些化合物减少无细胞的Hb和溶血。 还考虑活性化合物用于组合疗​​法，例如与施用红细胞和/或促进造血作用的药剂组合，或与施用一氧化氮供体组合使用。