AGR2 and TFF3 Regulation in the Diagnosis and Treatment of Cancer
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    发明申请
    AGR2 and TFF3 Regulation in the Diagnosis and Treatment of Cancer 审中-公开
    AGR2和TFF3在癌症诊断和治疗中的调控

    公开(公告)号:US20100062426A1

    公开(公告)日:2010-03-11

    申请号:US12092626

    申请日:2005-11-03

    IPC分类号: C12Q1/68

    CPC分类号: G01N33/57415 G01N33/574

    摘要: A method for assessing tumor progression is described by assessing AGR2 and/or TFF3 expression in a biological sample after induction of a physiological stress, such as hypoxia or serum deprivation in an enriched sample. Assessing the role of these indicators and their expression levels in an enriched CTC sample provides diagnostic and prognositic information on a patient. This method is also useful as a pharmatool in drug discovery.

    摘要翻译: 通过在诱导生理应激(例如富集样品中的缺氧或血清剥夺)之后评估生物样品中的AGR2和/或TFF3表达来描述评估肿瘤进展的方法。 评估这些指标及其在富集的CTC样品中的表达水平的作用提供了对患者的诊断和预后信息。 这种方法也可用作药物发现的药剂。