公开(公告)号：US08252747B2

公开(公告)日：2012-08-28

申请号：US12509687

申请日：2009-07-27

申请人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

发明人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

IPC分类号： A01N1/02 ,  A01N37/18 ,  A61F13/02 ,  A61K38/39

CPC分类号： A61L24/102 ,  A61L24/108

摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

摘要翻译： 组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。 密封剂非常适合单独粘合组织或与贴片组合。 醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。 当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

公开(公告)号：US07129210B2

公开(公告)日：2006-10-31

申请号：US10894609

申请日：2004-07-20

申请人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

发明人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

IPC分类号： A01N37/18 ,  A61K38/38 ,  A61K38/39 ,  A61F13/00 ,  A61F13/02

CPC分类号： A61L24/102 ,  A61L24/108

摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

摘要翻译： 组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。 密封剂非常适合单独粘合组织或与贴片组合。 醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。 当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

公开(公告)号：US20090287313A1

公开(公告)日：2009-11-19

申请号：US12509687

申请日：2009-07-27

申请人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

发明人： Johan Lowinger ,  Bruno Lowinger ,  Frank DeLustro ,  David Cox ,  David A. Browdie

IPC分类号： A61F2/02

CPC分类号： A61L24/102 ,  A61L24/108

摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.

摘要翻译： 组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。 密封剂非常适合单独粘合组织或与贴片组合。 醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。 当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

公开(公告)号：US06310036B1

公开(公告)日：2001-10-30

申请号：US09227400

申请日：1999-01-09

申请人： David A. Browdie

发明人： David A. Browdie

IPC分类号： A01N3718

CPC分类号： A61L24/102 ,  A61B17/00491 ,  A61B17/0057 ,  A61K38/39 ,  A61L24/10 ,  A61K2300/00

摘要： Disclosed is a novel tissue adhesive technology comprising a combination of ultrasonically treated proteins including collagen and albumin which form a viscous material that develops adhesive properties when chemically cross-linked. A novel new cross-linking agent with surprisingly stable properties was developed in association with the tissue adhesive described and claimed herein and is considered to be within the scope of the present invention. This new cross-linking agent is a product of reacting glutaraldehyde with amino acids or peptides and allowing the reaction to proceed to completion. This chemical cross-linker is mixed with the ultrasonically treated proteins, allowed to react for a pre-determined time, then used to seal large surface areas of vigorously bleeding tissues including, but not limited to, the liver, lungs and major vascular systems in patients with and without bleeding disorders. This same tissue adhesive has proven to work well in sealing suture sites to prevent leakage.

摘要翻译： 公开了一种新型组织粘合剂技术，其包括超声处理的蛋白质（包括胶原蛋白和白蛋白）的组合，其形成当化学交联时产生粘合性质的粘性材料。 与本文所述和要求保护的组织粘合剂相关联地开发出具有令人惊奇的稳定性质的新型交联剂，并被认为在本发明的范围内。 这种新的交联剂是使戊二醛与氨基酸或肽反应并使反应进行完成的产物。 将该化学交联剂与超声处理的蛋白质混合，允许反应预定时间，然后用于密封大量出血组织的大表面积，包括但不限于肝，肺和主要血管系统 有无出血性疾病的患者。 证明这种相同的组织粘合剂在密封缝合部位中能很好地起作用以防止泄漏。