FIBROBLAST GROWTH FACTOR-2 PROMOTES NEUROGENESIS AND NEUROPROTECTION AND PROLONGS SURVIVAL IN HUNTINGTON'S DISEASE
    2.
    发明申请
    FIBROBLAST GROWTH FACTOR-2 PROMOTES NEUROGENESIS AND NEUROPROTECTION AND PROLONGS SURVIVAL IN HUNTINGTON'S DISEASE 审中-公开
    FIBROBLAST GROWTH FACTOR-2促进神经病变和神经保护,并在亨廷顿病中存活

    公开(公告)号:US20090111748A1

    公开(公告)日:2009-04-30

    申请号:US11996178

    申请日:2006-07-21

    IPC分类号: A61K38/18

    CPC分类号: A61K38/1825

    摘要: This invention pertains to the discovery that fibroblast growth factor 2 (FGF2) stimulates neurogenesis, induces migration of newborn cells into the striatum and cortex, is neuroprotective, and significantly extends the lifespan mammals suffering from neurodegenerative conditions (e.g., Huntington's disease, Parkinson's disease, etc.). In certain embodiments this invention provides a method of promoting neurogenesis, neuroprotection and/or survival in a mammal having a neurodegenerative disease by upregulating expression or availability of endogenous fibroblast growth factor 2 (FGF2) in said mammal; and/or administering FGF2 or an FGF2 mutein to the mammal in an amount sufficient to promote neurogenesis, neuroprotection and/or survival of the mammal.

    摘要翻译: 本发明涉及成纤维细胞生长因子2(FGF2)刺激神经发生,诱导新生细胞迁移到纹状体和皮质中的神经保护作用的发现,并显着延长患有神经变性病症的哺乳动物(例如亨廷顿病,帕金森病, 等等。)。 在某些实施方案中,本发明提供了通过在所述哺乳动物中上调内源性成纤维细胞生长因子2(FGF2)的表达或可利用性来促进具有神经变性疾病的哺乳动物的神经发生,神经保护和/或存活的方法。 和/或以足以促进哺乳动物的神经发生,神经保护和/或存活的量向哺乳动物施用FGF2或FGF2突变蛋白。

    Shelving support bracket
    3.
    发明授权
    Shelving support bracket 失效
    货架支架

    公开(公告)号:US07506852B1

    公开(公告)日:2009-03-24

    申请号:US11544226

    申请日:2006-10-06

    IPC分类号: A47G29/02

    CPC分类号: A47B57/54 A47B57/04

    摘要: A shelving bracket for supporting an end of a shelf is adapted to be attachable at any location along the length of a heightwise extending pole. The bracket is adapted to bear against a side face of a pole and includes at least two guide surfaces engageable with front and rear faces of the pole to define the angle of orientation of the bracket and to maintain the bracket at that angle. The bracket is secured rigidly to the pole by a fastener. A second pole is provided with a similar shelf bracket. Each of the shelf brackets has a shelf-supporting ledge adapted to support an end of a shelf that spans between the poles.

    摘要翻译: 用于支撑搁架端部的搁架支架适于可沿着高度方向延伸的杆的长度的任何位置附接。 所述支架适于承受抵靠杆的侧面,并且包括至少两个可与所述杆的前表面和后表面接合的引导表面,以限定所述支架的取向角度并将支架保持在该角度。 支架通过紧固件牢固地固定在杆上。 第二极杆设有类似的支架。 每个搁架支架具有适于支撑横跨在两极之间的架子的端部的搁架支架。

    Resilient strip for protective strip assembly
    4.
    发明授权
    Resilient strip for protective strip assembly 失效
    用于保护条装配的弹性带

    公开(公告)号:US5283096A

    公开(公告)日:1994-02-01

    申请号:US873300

    申请日:1992-04-23

    IPC分类号: A47B95/04 E04F19/02 B60J11/00

    摘要: The invention features a flexible protective strip having one or more longtitudinally extending inserts which provide the protective strip with greater impact resistance, greater strength and an improved locking action in the mounting member. The resilient strip preferably includes a pair of oppositely disposed, inwardly extending latch members which include inserts to provide the improved locking action. The mounting member preferably includes a web portion having a pair of oppositely disposed web-latch extensions extending across a chord of the body, substantially parallel to a tangent to the circumference of the body at its mid-line, and at least one leg member extending from the web portion away from the body.

    摘要翻译: 本发明的特征在于具有一个或多个纵向延伸的插入件的柔性保护带,该插入件为保护带提供了更大的抗冲击性,更大的强度和在安装构件中的改进的锁定作用。 弹性带优选地包括一对相对设置的向内延伸的闩锁构件,其包括用于提供改进的锁定动作的插入件。 安装构件优选地包括腹板部分,腹板部分具有一对相对设置的腹板闩锁延伸部,其延伸穿过本体的弦线,基本上平行于主体在其中线处的圆周的切线,以及至少一个腿部件延伸 从腹部远离身体。