公开(公告)号：US07582439B2

公开(公告)日：2009-09-01

申请号：US11409944

申请日：2006-04-24

申请人： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

发明人： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC分类号： G01N33/536

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

摘要翻译： 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bim”，以及编码它们的遗传序列。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。

公开(公告)号：US20080027145A1

公开(公告)日：2008-01-31

申请号：US10588687

申请日：2005-02-03

申请人： David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

发明人： David C. S. Huang ,  Peter M. Colman ,  Catherine L. Day ,  Jerry M. Adams ,  Lin Chen ,  Simon N. Willis ,  Andrew Wei ,  Brian J. Smith ,  Mark G. Hinds

IPC分类号： A61K35/00 ,  A61P35/00 ,  G01N33/48 ,  G01N33/53

CPC分类号： C07K14/4747

摘要： The present invention relates generally to therapeutic molecules useful for inducing apoptosis of particular cells such as, but not limited to, cancer cells and methods for generating and/or selecting same. The present invention further provides methods for inducing apoptosis of cells such as cancer cells and pharmaceutical compositions useful for same. The present invention further provides methods for generating or selecting therapeutic agents capable of inducing apoptosis of particular cells by the selective inhibition of pro-survival proteins. The present invention further provides a computational approach to therapeutic molecule design based on structure-binding characteristics.

摘要翻译： 本发明一般涉及用于诱导特定细胞凋亡的治疗分子，所述特定细胞例如但不限于癌细胞，以及用于产生和/或选择癌细胞的方法。 本发明还提供诱导细胞凋亡的方法，例如癌细胞和对其有用的药物组合物。 本发明还提供了通过选择性抑制前体存活蛋白来产生或选择能够诱导特定细胞凋亡的治疗剂的方法。 本发明还提供了基于结构结合特征的治疗分子设计的计算方法。

公开(公告)号：US07064193B1

公开(公告)日：2006-06-20

申请号：US09508832

申请日：1998-09-17

申请人： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

发明人： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC分类号： C12N15/11 ,  C07K14/00

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.