公开(公告)号：US20140243302A1

公开(公告)日：2014-08-28

申请号：US14126225

申请日：2012-06-26

申请人： Yasumichi Fukuda ,  David E. Kaelin, JR. ,  Sheo B. Singh

发明人： Yasumichi Fukuda ,  David E. Kaelin, JR. ,  Sheo B. Singh

IPC分类号： A61K31/542 ,  A61K31/5377 ,  A61K31/498 ,  A61K31/4375 ,  A61K45/06 ,  C07D513/04 ,  C07D498/04 ,  C07D471/04 ,  C07D491/056 ,  A61K31/5383 ,  C07D515/04

CPC分类号： A61K31/542 ,  A61K31/4375 ,  A61K31/498 ,  A61K31/5377 ,  A61K31/5383 ,  A61K45/06 ,  C07D471/04 ,  C07D491/056 ,  C07D493/08 ,  C07D495/08 ,  C07D498/04 ,  C07D513/04 ,  C07D515/04 ,  Y02A50/401

摘要： Novel bridged bicyclic compounds are disclosed herein, along with their pharmaceutically acceptable salts, hydrates and prodrugs. Also disclosed are compositions comprising such compounds, methods of preparing such compounds and methods of using such compounds as antibacterial agents. The disclosed compounds, their pharmaceutically acceptable salts, hydrates and prodrugs, as well as compositions comprising such compounds, salts, hydrates and prodrugs, are useful for treating bacterial infections and associated diseases and conditions.

摘要翻译： 本文公开了新的桥连双环化合物及其药学上可接受的盐，水合物和前药。 还公开了包含这种化合物的组合物，制备这些化合物的方法和使用这些化合物作为抗菌剂的方法。 所公开的化合物，其药学上可接受的盐，水合物和前药，以及包含这些化合物，盐，水合物和前药的组合物可用于治疗细菌感染和相关疾病和病症。

公开(公告)号：US07671073B2

公开(公告)日：2010-03-02

申请号：US11579265

申请日：2005-05-13

申请人： Joseph L. Duffy ,  David E. Kaelin, Jr. ,  Ann E. Weber ,  Brian A Kirk

发明人： Joseph L. Duffy ,  David E. Kaelin, Jr. ,  Ann E. Weber ,  Brian A Kirk

IPC分类号： A61K31/44 ,  A61K31/41 ,  A61K31/42 ,  A61K31/415 ,  A61K31/40 ,  C07D401/10 ,  C07D271/06 ,  C07D263/24 ,  C07D249/16

CPC分类号： C07D207/27 ,  C07D207/10 ,  C07D211/38 ,  C07D401/08 ,  C07D401/12 ,  C07D413/08 ,  C07D471/04

摘要： The present invention is directed to novel cyclohexylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新型环己基丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。