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公开(公告)号：US07794750B2
公开(公告)日：2010-09-14
申请号：US12330280
申请日：2008-12-08
CPC分类号： A61K31/554 , A61K9/2027 , A61K9/2054
摘要： The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions.
摘要翻译： 本发明包括具有基质的控释组合物。 基质含有药学有效量的活性剂或其药学上可接受的盐或溶剂合物，离子型非胶凝基质聚合物和pH调节剂。 离子型非胶凝基质聚合物在第一水溶液pH下几乎是不溶的和不可溶的，并且在第二水性流体pH下是可溶的。 pH调节剂以控制活性剂从组合物释放的量存在。 控释组合物基本上不含胶凝或溶胀性赋形剂，并且不含有功能性涂层或亲油性组分。 本发明还提供了制备和使用控释组合物的方法。
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公开(公告)号：US20090317473A1
公开(公告)日：2009-12-24
申请号：US12143460
申请日：2008-06-20
IPC分类号： A61K9/14
CPC分类号： A61K9/2018 , A61K9/2009 , A61K9/2027 , A61K9/2077
摘要： The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt, solvate, ester, and/or prodrug thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient. The present invention also provides methods of making and using the controlled-release compositions.
摘要翻译： 本发明包括具有基质的控释组合物。 基质含有药学有效量的活性剂或其药学上可接受的盐，溶剂化物，酯和/或前药，离子型非胶凝基质聚合物和pH调节剂。 离子型非胶凝基质聚合物在第一水溶液pH下几乎是不溶的和不可溶的，并且在第二水性流体pH下是可溶的。 pH调节剂以控制活性剂从组合物释放的量存在。 控释组合物基本上不含胶凝或溶胀性赋形剂。 本发明还提供了制备和使用控释组合物的方法。
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公开(公告)号：US20090317471A1
公开(公告)日：2009-12-24
申请号：US12330280
申请日：2008-12-08
IPC分类号： A61K9/14 , A61K31/554 , A61P43/00 , A61K9/22 , A61K9/52
CPC分类号： A61K31/554 , A61K9/2027 , A61K9/2054
摘要： The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions.
摘要翻译： 本发明包括具有基质的控释组合物。 基质含有药学有效量的活性剂或其药学上可接受的盐或溶剂合物，离子型非胶凝基质聚合物和pH调节剂。 离子型非胶凝基质聚合物在第一水溶液pH下几乎是不溶的和不可溶的，并且在第二水性流体pH下是可溶的。 pH调节剂以控制活性剂从组合物释放的量存在。 控释组合物基本上不含胶凝或溶胀性赋形剂，并且不含有功能性涂层或亲油性组分。 本发明还提供了制备和使用控释组合物的方法。
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公开(公告)号：US08632805B2
公开(公告)日：2014-01-21
申请号：US12143460
申请日：2008-06-20
IPC分类号： A61K9/22
CPC分类号： A61K9/2018 , A61K9/2009 , A61K9/2027 , A61K9/2077
摘要： The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt, solvate, ester, and/or prodrug thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient. The present invention also provides methods of making and using the controlled-release compositions.
摘要翻译： 本发明包括具有基质的控释组合物。 基质含有药学有效量的活性剂或其药学上可接受的盐，溶剂合物，酯和/或前药，离子型非胶凝基质聚合物和pH调节剂。 离子型非胶凝基质聚合物在第一水溶液pH下几乎是不溶的和不可溶的，并且在第二水性流体pH下是可溶的。 pH调节剂以控制活性剂从组合物释放的量存在。 控释组合物基本上不含胶凝或溶胀性赋形剂。 本发明还提供了制备和使用控释组合物的方法。
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