公开(公告)号：US08920806B2

公开(公告)日：2014-12-30

申请号：US10575049

申请日：2004-10-06

Applicant: David Morritz De Kretser ,  David James Phillips ,  Kristian Lee Jones ,  Robyn O'Hehir ,  Shane Patella

Inventor： David Morritz De Kretser ,  David James Phillips ,  Kristian Lee Jones ,  Robyn O'Hehir ,  Shane Patella

IPC: A61K39/00 ,  C07K16/26 ,  A61K38/17

CPC classification number: A61K38/1709 ,  C07K16/26

Abstract: The present invention relates generally to a method of modulating an inflammatory response in a mammal and to agents useful for same. More particularly, the present invention relates to a method of modulating an inflammatory response in a mammal by modulating the functional activity of activin and thereby modulating the pro-inflammatory mediator cascade. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by an aberrant, unwanted or otherwise inappropriate inflammatory response including, inter alia, sepsis and inflammation of the airway. The present invention is further directed to methods for identifying and/or designing agents capable of modulating activin mediated regulation of the inflammatory response.

Abstract translation: 本发明一般涉及一种调节哺乳动物炎症反应的方法以及可用于其的药剂。 更具体地说，本发明涉及通过调节激活素的功能活性从而调节促炎介质级联来调节哺乳动物炎症反应的方法。 本发明的方法尤其可用于治疗和/或预防特征在于异常，不想要的或其它不适当的炎症反应的病症，特别是包括气道的败血症和炎症。 本发明还涉及用于鉴定和/或设计能够调节激活素介导的炎性反应调节的药剂的方法。