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公开(公告)号：US07837913B2
公开(公告)日：2010-11-23
申请号：US11200982
申请日：2005-08-10
申请人： Jeff S. Sakamoto , James R. Weiss , Jean-Pierre Fleurial , Adam Kisor , Mark Tuszynski , Shula Stokols , Todd Edward Holt , David James Welker , Christopher David Breckon
发明人： Jeff S. Sakamoto , James R. Weiss , Jean-Pierre Fleurial , Adam Kisor , Mark Tuszynski , Shula Stokols , Todd Edward Holt , David James Welker , Christopher David Breckon
CPC分类号： A61L27/56 , A61L31/14 , Y10S977/896 , Y10T428/249964 , Y10T428/29
摘要： Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers.
摘要翻译： 公开了使用多组分聚合物纤维基质制造的毫米至纳米级结构。 使用不同的聚合物允许在制造过程的各个阶段选择性地溶解聚合物。 在一个应用中，可以形成具有长孔长度和小孔径的生物相容性基质。 制造过程从布置在由第二聚合物纤维形成的基体中的第一聚合物纤维开始。 可以连接端盖以提供结构支撑，并且聚合物纤维基质选择性地溶解掉，仅留下长的聚合物纤维。 这些可能暴露于另一种产品，例如生物相容性凝胶，以形成生物相容性基质。 然后可以选择性地溶解聚合物纤维，仅留下具有由溶解的聚合物纤维形成的孔的生物相容的凝胶支架。
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公开(公告)号：US20100055144A1
公开(公告)日：2010-03-04
申请号：US11200982
申请日：2005-08-10
申请人： Jeff S. Sakamoto , James R. Weiss , Jean-Pierre Fleurial , Adam Kisor , Mark Tuszynski , Shula Stokols , Todd Edward Holt , David James Welker , Christopher David Breckon
发明人： Jeff S. Sakamoto , James R. Weiss , Jean-Pierre Fleurial , Adam Kisor , Mark Tuszynski , Shula Stokols , Todd Edward Holt , David James Welker , Christopher David Breckon
CPC分类号： A61L27/56 , A61L31/14 , Y10S977/896 , Y10T428/249964 , Y10T428/29
摘要： Millimeter to nano-scale structures manufactured using a multi-component polymer fiber matrix are disclosed. The use of dissimilar polymers allows the selective dissolution of the polymers at various stages of the manufacturing process. In one application, biocompatible matrixes may be formed with long pore length and small pore size. The manufacturing process begins with a first polymer fiber arranged in a matrix formed by a second polymer fiber. End caps may be attached to provide structural support and the polymer fiber matrix selectively dissolved away leaving only the long polymer fibers. These may be exposed to another product, such as a biocompatible gel to form a biocompatible matrix. The polymer fibers may then be selectively dissolved leaving only a biocompatible gel scaffold with the pores formed by the dissolved polymer fibers.
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