公开(公告)号：US4052390A

公开(公告)日：1977-10-04

申请号：US574870

申请日：1975-05-06

申请人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

发明人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

IPC分类号： C07D487/04 ,  A61K31/505

CPC分类号： C07D487/04 ,  Y10S514/826

摘要： 8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

公开(公告)号：US3933822A

公开(公告)日：1976-01-20

申请号：US478387

申请日：1974-06-11

申请人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

发明人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

IPC分类号： C07D487/02 ,  C07D471/04 ,  C07D487/04 ,  C07D239/00

CPC分类号： C07D487/04 ,  C07D471/04 ,  Y10S514/826

摘要： 8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.

摘要翻译： 在2-位被亚氨基磺酰基取代基的间位取代的8-亚氨基-6-取代基和相对于所述氨磺酰基的羟基，烷氧基或烷硫基取代基对及其药学上可接受的盐 具有用于治疗过敏性呼吸系统疾病例如过敏性支气管哮喘的药理学性质。

公开(公告)号：US4039544A

公开(公告)日：1977-08-02

申请号：US680444

申请日：1976-04-26

申请人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

发明人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

IPC分类号： C07D239/46 ,  C07D239/48 ,  C07D487/04

CPC分类号： C07D239/47 ,  C07D239/46 ,  C07D239/48 ,  C07D487/04

摘要： The invention provides certain novel 8-azapurin-6-one derivatives substituted in the 2-position by a substituted phenyl group, preferably carrying an alkoxy in the 2-position, which possess valuable pharmacological properties especially in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.

摘要翻译： 本发明提供在2-位被取代的苯基取代的某些新的8-氮杂青霉素-6-酮衍生物，优选地具有2-位的烷氧基，其具有有价值的药理学性质，特别是在治疗由 组织固定抗体与特异性抗原的相互作用。

公开(公告)号：US3987160A

公开(公告)日：1976-10-19

申请号：US364425

申请日：1973-05-29

申请人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

发明人： Barbara Joyce Broughton ,  Bryan John Large ,  Stuart Malcolm Marshall ,  David Lord Pain ,  Kenneth Robert Harry Wooldridge

IPC分类号： C07D239/46 ,  C07D239/48 ,  C07D317/68 ,  C07D487/04 ,  A61K31/505 ,  A61L9/04

CPC分类号： C07D239/47 ,  C07D239/48 ,  C07D317/68 ,  C07D487/04 ,  Y02P20/55

摘要： 8-Azapurin-6-ones substituted in the 2-position by an unsubstituted or substituted phenyl or naphthyl group, or by an alkenyl or alkynyl group, a cycloalkyl group, an alkyl group contaning 2 to 10 carbon atoms, or an alkyl group containing 1 to 10 carbon atoms carrying one or more substitutents selected from halogen atoms and hydroxy, cycloalkyl, alkoxy, phenyl and substituted phenyl groups, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful, for example, in the treatment of allergic bronchial asthma.