公开(公告)号：US5232707A

公开(公告)日：1993-08-03

申请号：US759803

申请日：1991-09-13

Applicant: David M. Lokensgard

Inventor： David M. Lokensgard

IPC: A61K9/16 ,  B01J13/20

CPC classification number: B01J13/206 ,  A61K9/1694

Abstract: There is disclosed a process for the extraction of volatile solvents entrained in a polymer-based pharmaceutical composition designed for sustained release of drug over an extended period of time prepared in microcapsule form wherein the composition comprises at least one hormonally active water-soluble polypeptide in an effective amount greater than a conventional single dose and a biocompatible, bioerodable encapsulating polymer, which process comprises the steps of contacting the composition to a stream of dense gas, that is, pressurized gas and then removing the dense gas, and volatile solvents contained therein, extracted from the pharmaceutical composition.

Abstract translation: 公开了一种方法，用于提取夹带在基于聚合物的药物组合物中的挥发性溶剂，所述药物组合物设计用于在微胶囊形式制备的延长的时间段内持续释放药物，其中组合物包含至少一种激素活性水溶性多肽 有效量大于常规单剂量和生物相容的可生物侵蚀的包封聚合物，该方法包括以下步骤：将组合物与致密气体流（即加压气体，然后除去致密气体，以及其中所含的挥发性溶剂）接触， 从药物组合物中提取。

公开(公告)号：US08293871B2

公开(公告)日：2012-10-23

申请号：US11578712

申请日：2005-04-15

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine Smith ,  David M. Lokensgard ,  Mark Fineman ,  John Ong

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Henry R. Costantino ,  Christine Smith ,  David M. Lokensgard ,  Mark Fineman ,  John Ong

IPC: A61K38/00

CPC classification number: A61K47/34 ,  A61K9/0024 ,  A61K9/1623 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/2278 ,  A61K38/26 ,  A61K47/26 ,  A61K47/38

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

Abstract translation: 本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。 本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

公开(公告)号：US20080119569A1

公开(公告)日：2008-05-22

申请号：US11878160

申请日：2007-07-20

Applicant: Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David M. Lokensgard ,  Henry R. Costantino

Inventor： Steven G. Wright ,  Troy Christensen ,  Thean Yeoh ,  Michael E. Rickey ,  Joyce M. Hotz ,  Rajesh Kumar ,  Mark Fineman ,  Christine Smith ,  John Ong ,  David M. Lokensgard ,  Henry R. Costantino

IPC: A61K47/00

CPC classification number: A61K47/34 ,  A61K9/0002 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5089 ,  A61K31/573 ,  A61K38/2278 ,  A61K38/26

Abstract: This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.