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公开(公告)号：US20100210527A1
公开(公告)日：2010-08-19
申请号：US12530596
申请日：2008-03-10
CPC分类号： C12N15/1136 , A61K31/535 , C12N2310/11 , C12N2310/3233 , C12N2320/33
摘要： The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favours proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favours distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
摘要翻译： 本发明提供了一种哺乳动物受试者的选择性前体或反 - 血管生成治疗方法，包括使用控制剂进行剪接处理从VEGF基因的C末端外显子8转录的VEGF前体mRNA处理期间的选择性剪接的位点特异性控制 其中在促血管生成治疗中使用有利于所述处理中的近端剪接位点（PSS）剪接的一种或多种控制剂，并且在所述处理中使用有利于所述处理中的远端剪接位点（DSS）剪接的一种或多种控制剂， 血管生成治疗。
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公开(公告)号：US09447418B2
公开(公告)日：2016-09-20
申请号：US12530596
申请日：2008-03-10
IPC分类号： A61K38/16 , C12N15/113 , A61K31/535
CPC分类号： C12N15/1136 , A61K31/535 , C12N2310/11 , C12N2310/3233 , C12N2320/33
摘要： The invention provides a method of selectively pro-oranti-angiogenic treatment of a mammalian subject, comprising site-specific control of alternative splicing during processing of VEGF pre-mRNA transcribed from the C terminal exon 8 of the VEGF gene using controlling agents for the splicing, wherein one or more controlling agent which favors proximal splice site (PSS) splicing in said processing is used in the pro-angiogenic treatment and one or more controlling agent which favors distal splice site (DSS) splicing in said processing is used in the anti-angiogenic treatment.
摘要翻译： 本发明提供了一种哺乳动物受试者的选择性前体或反 - 血管生成治疗方法，包括使用控制剂进行剪接处理从VEGF基因的C末端外显子8转录的VEGF前体mRNA处理期间的选择性剪接的位点特异性控制 其中在促血管生成治疗中使用有利于所述处理中的近端剪接位点（PSS）剪接的一种或多种控制剂，并且在所述处理中使用有利于所述处理中的远端剪接位点（DSS）剪接的一种或多种控制剂， 血管生成治疗。
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