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公开(公告)号：US20200015786A1
公开(公告)日：2020-01-16
申请号：US16368986
申请日：2019-03-29
发明人： Nebojsa Duric , Peter LITTRUP , Cuiping LI
摘要： A method and system for generating an enhanced image of a volume of tissue, comprising: emitting acoustic waveforms toward the volume of tissue; detecting acoustic signals derived from acoustic waveforms interacting with the volume of tissue; generating a reflection rendering of a region of the volume of tissue; generating at least one of a sound speed map and an attenuation map of the region of the volume of tissue; generating a transfer map derived from a set of sound speed parameter values of the sound speed map and/or a set of acoustic attenuation parameter values of the acoustic attenuation map, the set of sound speed parameter values and the set of acoustic attenuation parameters associated with the set of elements of the region of the volume of tissue; and rendering an enhanced image of the volume of tissue, derived from processing of the reflection rendering with the transfer map.
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2.发明授权公开(公告)号：US10368831B2
公开(公告)日：2019-08-06
申请号：US15829748
申请日：2017-12-01
摘要： The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.
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公开(公告)号：US20190142367A1
公开(公告)日：2019-05-16
申请号：US16212760
申请日：2018-12-07
发明人： Carri GLIDE-HURST , Nebojsa DURIC , Peter LITTRUP
摘要： A method for categorizing whole-breast density is disclosed. The method includes the steps of exposing breast tissue to an acoustic signal; measuring a distribution of an acoustic parameter by analyzing the acoustic signal; and obtaining a measure of whole-breast density from said measuring step. An apparatus is also disclosed.
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公开(公告)号：US09763641B2
公开(公告)日：2017-09-19
申请号：US14015459
申请日：2013-08-30
发明人： Erik West , Olivier Roy , Steven Schmidt
CPC分类号： A61B8/0825 , A61B8/15 , A61B8/406 , A61B8/4494
摘要： A method and system for imaging a volume of tissue and defining a tissue boundary comprising: receiving a baseline dataset representative of a first set of signals interacting with a medium; receiving a reconstruction dataset representative of a second set of signals interacting with the medium and the volume of tissue present in the medium; determining a set of direct emitter-receiver pairs, each defining a direct trajectory that does not pass through the volume of tissue; from the set of direct emitter-receiver pairs, determining a set of tangential emitter-receiver pairs, each defining a bounding vector comprising a tangent point along the tissue boundary; determining a set of interior pixels, of the reconstruction dataset, characterized by a set of pixel locations within the tissue boundary; and reconstructing pixels of the set of interior pixels, thereby transforming the baseline and the reconstruction datasets into an image rendering of the volume of tissue.
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公开(公告)号：US20130303895A1
公开(公告)日：2013-11-14
申请号：US13894202
申请日：2013-05-14
IPC分类号： A61B19/00
CPC分类号： A61B34/20 , A61B8/0825 , A61B8/0841 , A61B8/403 , A61B8/406 , A61B17/3403 , A61B90/17 , A61B2017/3411 , A61B2017/3413
摘要： A system and method for performing an image-guided biopsy of a target mass of a volume of tissue comprising: a transducer array comprising a set of ultrasound emitters and a set of ultrasound receivers configured to generate a set of acoustic data based upon acoustic waveforms received from the volume of tissue, wherein the transducer array is configured to enable determination of a location of the target mass based on the set of acoustic data; a base proximate to the transducer array; a fixation plate coupled to the base and cooperating with the base and the transducer array to at least partially define an adjustable receiving space configured to receive the volume of tissue; and a guiding module coupled to the base and comprising an aperture configured to align a biopsy tool with the location of the target mass.
摘要翻译： 一种用于对组织体积的目标质量进行图像引导的活组织检查的系统和方法，包括：包括一组超声波发射器的一组换能器阵列和被配置成基于所接收的声波产生一组声学数据的一组超声波接收器 其中所述换能器阵列被配置为能够基于所述声学数据集合来确定所述目标质量块的位置; 靠近换能器阵列的基座; 耦合到所述基座并与所述基座和所述换能器阵列配合的固定板，以至少部分地限定被配置为接收所述体积的组织的可调节接收空间; 以及引导模块，其联接到所述基座并且包括孔，所述孔被配置为将活检工具与所述目标块的位置对准。
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6.发明申请公开(公告)号：US20210035296A1
公开(公告)日：2021-02-04
申请号：US17076384
申请日：2020-10-21
摘要： Disclosed herein systems, processors, or computer-readable media configured with instructions to: receive transmission and/or reflection images of a tissue of a subject, wherein the images are generated from acoustic signals derived from acoustic waveforms transmitted through the tissue; provide a set of prognostic parameters associated with a user selected region of interest; wherein the set of prognostic parameters comprises sound propagation metrics characterizing sound propagation within a tissue; wherein the set of prognostic parameters corresponds to inputs into a tissue classifier model; wherein the set of prognostic parameters comprises a plurality of subsets of related feature groupings; and determine a type of tissue of the subject based on said plurality of subsets of related feature groupings using the classifier model, wherein the type of tissue is a cancerous tumor, a fibroadenoma, a cyst, a nonspecific benign mass, and an unidentifiable mass.
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7.发明申请公开(公告)号：US20200022672A1
公开(公告)日：2020-01-23
申请号：US16443993
申请日：2019-06-18
摘要： The present invention provides improved methods and systems for generating enhanced images of a volume of tissue. In an aspect, the method comprises receiving from a transducer, a plurality of acoustic signals derived from acoustic waveforms transmitted through the volume of tissue; generating from the acoustic signals, a first reflection rendering that characterizes sound reflection, the first reflection rendering comprising a first distribution of reflection values across a region of the volume of tissue; generating from the acoustic signals, a sound speed rendering that characterizes sound speed, the sound speed rendering comprising a distribution of sound speed values across the region; generating from the sound speed rendering, a second reflection rendering that characterizes sound reflection, the second reflection rendering comprising a second distribution of reflection values across the region; and rendering one or more combined images, based on the first reflection rendering and the second reflection rendering.
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公开(公告)号：US20200015775A1
公开(公告)日：2020-01-16
申请号：US16367362
申请日：2019-03-28
发明人： Peter John Littrup , Nebojsa DURIC
摘要： A method of characterizing the pathological response of tissue to a treatment plan, including: obtaining a set of sequential morphology renderings of the tissue, wherein each rendering corresponds to a particular point in time during the treatment plan; generating a set of representative values of a biomechanical property of the tissue for the set of renderings, wherein each representative value is based on a corresponding rendering; determining a trend of the biomechanical property based on the set of representative values; and predicting response of the tissue to the treatment plan based on the trend of the biomechanical property.
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公开(公告)号：US10251622B2
公开(公告)日：2019-04-09
申请号：US16113863
申请日：2018-08-27
发明人： Mike Tesic , Marc Orloff , Kevin Obrigkeit , David Kunz , Roman Janer
摘要： A system for providing scanning medium for scanning a volume of tissue comprising: an inner chamber that contains the scanning medium; a transducer mounted to the inner chamber and configured to move along a motion path, with the inner chamber, in scanning the volume of tissue; an outer chamber concentrically aligned about the inner chamber to guide the inner chamber along the motion path; a piston module defining a base surface within the inner chamber, the piston module comprising a medium inlet and a medium outlet for adjusting an amount of the scanning medium within the inner chamber; a detection subsystem coupled to the base surface of the piston module; and an actuator comprising a stationary portion mounted to the piston module and a moving portion coupled to the inner chamber and configured to produce motion of the inner chamber along the motion path.
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公开(公告)号：US10231696B2
公开(公告)日：2019-03-19
申请号：US15731000
申请日：2017-10-12
发明人： Nebojsa Duric , Peter John Littrup
摘要： A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.
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