公开(公告)号：US20100233741A1

公开(公告)日：2010-09-16

申请号：US12723595

申请日：2010-03-12

申请人： Joanne Wang ,  Hong Zhu ,  Dianne D. Hodges ,  Ester Fernandez-Salas

发明人： Joanne Wang ,  Hong Zhu ,  Dianne D. Hodges ,  Ester Fernandez-Salas

IPC分类号： G01N33/53

CPC分类号： G01N33/573 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  C12N9/50 ,  C12Q1/37 ,  C12Y304/24069 ,  G01N33/5014 ,  G01N33/5035 ,  G01N33/53 ,  G01N2333/33 ,  G01N2333/47 ,  G01N2333/952 ,  G01N2333/96425

摘要： The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, α-SNAP-25 antibodies that selectively bind to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, methods of detecting retargeted endopeptidase activity, and methods of detecting neutralizing α-re-targeted endopeptidase antibodies.

摘要翻译： 本说明书公开了SNAP-25免疫应答诱导组合物，制备选择性结合包含在BoNT / A切割位点剪切键的P1残基处具有羧基末端的SNAP-25的表位的α-SNAP-25抗体的方法 ，选择性结合包含在BoNT / A切割位点剪切键的P1残基处具有羧基末端的SNAP-25的表位的α-SNAP-25抗体，检测重靶向内肽酶活性的方法和检测中和α的方法 靶向内肽酶抗体。

公开(公告)号：US08455203B2

公开(公告)日：2013-06-04

申请号：US12723595

申请日：2010-03-12

申请人： Joanne Wang ,  Hong Zhu ,  Dianne D. Hodges ,  Ester Fernandez-Salas

发明人： Joanne Wang ,  Hong Zhu ,  Dianne D. Hodges ,  Ester Fernandez-Salas

IPC分类号： G01N33/53

CPC分类号： G01N33/573 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  C12N9/50 ,  C12Q1/37 ,  C12Y304/24069 ,  G01N33/5014 ,  G01N33/5035 ,  G01N33/53 ,  G01N2333/33 ,  G01N2333/47 ,  G01N2333/952 ,  G01N2333/96425

摘要： The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, α-SNAP-25 antibodies that selectively bind to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, methods of detecting retargeted endopeptidase activity, and methods of detecting neutralizing α-re-targeted endopeptidase antibodies.

摘要翻译： 本说明书公开了SNAP-25免疫应答诱导组合物，制备选择性结合包含在BoNT / A切割位点剪切键的P1残基处具有羧基末端的SNAP-25的表位的α-SNAP-25抗体的方法 选择性结合包含在BoNT / A切割位点剪切键的P1残基处具有羧基末端的SNAP-25的表位的α-SNAP-25抗体，检测重靶向内肽酶活性的方法和检测中和α的方法 靶向内肽酶抗体。