公开(公告)号：US08519106B2

公开(公告)日：2013-08-27

申请号：US12530764

申请日：2008-03-13

申请人： Christoph Esslinger ,  Sandra Künzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jäger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Göbels

发明人： Christoph Esslinger ,  Sandra Künzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jäger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Göbels

IPC分类号： C12P21/08

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K49/0002 ,  C07K16/3053 ,  C07K2317/21

摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.

摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。

公开(公告)号：US07125681B2

公开(公告)日：2006-10-24

申请号：US10176038

申请日：2002-06-21

申请人： Alexander Knuth ,  Elke Jäger ,  Dirk Jäger

发明人： Alexander Knuth ,  Elke Jäger ,  Dirk Jäger

IPC分类号： G01N33/574 ,  C12Q1/58 ,  C07K16/30

CPC分类号： G01N33/574 ,  G01N33/6854

摘要： The present invention provides methods and diagnostic kits for the detection of disease-specific antibodies in urine containing sample. The present invention is also directed toward methods for determining that a patient suffers from a disorder characterized by aberrant expression of a naturally occurring gene. Methods for monitoring the status of a disorder in a patient characterized by aberrant expression of a naturally occurring gene are also provided.