公开(公告)号：US06624200B2

公开(公告)日：2003-09-23

申请号：US09877218

申请日：2001-06-11

申请人： William J. Bologna ,  Howard L. Levine ,  Dominque DeZiegler

发明人： William J. Bologna ,  Howard L. Levine ,  Dominque DeZiegler

IPC分类号： A01N3302

CPC分类号： A61K9/006 ,  A61K9/2027 ,  A61K9/2054

摘要： A bioadhesive composition wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process and more importantly may be protected from moisture and the immediate septic environment until after the patient has applied the composition, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the composition is available for absorption (bioavailable).