公开(公告)号：US20110319383A1

公开(公告)日：2011-12-29

申请号：US12599861

申请日：2007-11-16

Applicant: Daniel Brown ,  Donna Caster ,  Brian Clark ,  Sandra Hopkins ,  Jennifer Llewelyn ,  Lisa Martin ,  Elizabeth Meehan ,  Robert Timko ,  Husheng Yang

Inventor： Daniel Brown ,  Donna Caster ,  Brian Clark ,  Sandra Hopkins ,  Jennifer Llewelyn ,  Lisa Martin ,  Elizabeth Meehan ,  Robert Timko ,  Husheng Yang

IPC: A61K31/554 ,  A61P25/18

CPC classification number: A61K9/2018 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/554

Abstract: The present invention relates to extended release formulations of quetiapine and its pharmaceutically acceptable salts. The formulations comprise polymers, preferably hydroxypropyl methylcellulose of different viscosities, selected to cause the formulations to conform to preselected quetiapine release profiles. A process for the manufacture of said formulations is also disclosed.

Abstract translation: 本发明涉及喹硫平及其药学上可接受的盐的延长释放制剂。 制剂包含聚合物，优选不同粘度的羟丙基甲基纤维素，其被选择以使制剂符合预选的喹硫平释放曲线。 还公开了制备所述制剂的方法。

公开(公告)号：US20080287418A1

公开(公告)日：2008-11-20

申请号：US11939585

申请日：2007-11-14

Applicant: Daniel Brown ,  Donna Caster ,  Brian Clark ,  Sandra Hopkins ,  Jennifer Llewelyn ,  Elizabeth Meehan ,  Lisa Martin ,  Robert Timko ,  Husheng Yang

Inventor： Daniel Brown ,  Donna Caster ,  Brian Clark ,  Sandra Hopkins ,  Jennifer Llewelyn ,  Elizabeth Meehan ,  Lisa Martin ,  Robert Timko ,  Husheng Yang

IPC: A61K31/554 ,  A61P25/18

CPC classification number: A61K9/2018 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/554

Abstract: Extended release formulations of quetiapine and its pharmaceutically salts, and methods for manufacture of the formulations, may include the use of polymers selected for their physical and chemical characteristics. The formulations may include polymers selected to cause solid dosage forms of the formulations to conform to preselected quetiapine release criteria. The formulations may include non-polymer materials that may affect quetiapine release.

Abstract translation: 喹硫平及其药学上盐的延长释放制剂和制剂的制备方法可包括使用根据其物理和化学特性选择的聚合物。 制剂可以包括选择用于使制剂的固体剂型符合预选的喹硫平释放标准的聚合物。 制剂可以包括可能影响喹硫平释放的非聚合物材料。