公开(公告)号：US20050026184A1

公开(公告)日：2005-02-03

申请号：US10849244

申请日：2004-05-20

申请人： Gregory Plowman ,  Douglas Clary

发明人： Gregory Plowman ,  Douglas Clary

IPC分类号： C07K14/705 ,  C12N9/12 ,  C12N9/16 ,  C12Q1/68 ,  C07H21/04 ,  G01N33/574

CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/16

摘要： The present invention relates to ALK-7 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for ALK-7 related diseases or conditions characterized by an abnormal interaction between an ALK-7 polypeptide and an ALK-7 binding partner.

摘要翻译： 本发明涉及ALK-7多肽，编码这种多肽的核酸，含有此类核酸的细胞，组织和动物，这种多肽的抗体，利用这些多肽的测定法，以及涉及上述所有方法的方法。 提供ALK-7相关疾病或ALK-7多肽与ALK-7结合配偶体异常相互作用特征的治疗，诊断和筛选方法。

公开(公告)号：US06818440B2

公开(公告)日：2004-11-16

申请号：US09069228

申请日：1998-04-27

申请人： Gregory D. Plowman ,  Douglas Clary

发明人： Gregory D. Plowman ,  Douglas Clary

IPC分类号： C12N1563

CPC分类号： C12N9/1205 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/16

摘要： The present invention relates to ALK-7 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating to all of the foregoing. Methods for treatment, diagnosis, and screening are provided for ALK-7 related diseases or conditions characterized by an abnormal interaction between an ALK-7 polypeptide and an ALK-7 binding partner.

摘要翻译： 本发明涉及ALK-7多肽，编码这种多肽的核酸，含有此类核酸的细胞，组织和动物，这种多肽的抗体，利用这些多肽的测定法，以及涉及上述所有方法的方法。 提供ALK-7相关疾病或ALK-7多肽与ALK-7结合配偶体异常相互作用特征的治疗，诊断和筛选方法。

公开(公告)号：US20060216730A1

公开(公告)日：2006-09-28

申请号：US11320072

申请日：2005-12-29

申请人： Gregory Plowman ,  David Whyte ,  Gerard Manning ,  Sucha Sudarsanam ,  Ricardo Martinez ,  Peter Flanagan ,  Douglas Clary

发明人： Gregory Plowman ,  David Whyte ,  Gerard Manning ,  Sucha Sudarsanam ,  Ricardo Martinez ,  Peter Flanagan ,  Douglas Clary

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： G01N33/6896 ,  C12Q1/485 ,  G01N33/57407 ,  G01N33/6893

摘要： The present invention relates to kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a bioinformatics strategy, mammalian members of the of PTK's and STK's have been identified and their protein structure predicted.

公开(公告)号：US06235769B1

公开(公告)日：2001-05-22

申请号：US09109883

申请日：1998-07-02

申请人： Douglas Clary

发明人： Douglas Clary

IPC分类号： A61K3140

CPC分类号： A61K31/40

摘要： The invention relates in part to a method of preventing or treating an abnormal condition caused by an aberration in the function of the C-RET receptor, and specifically to the treatment and prevention of neurodegenerative disorders by administering a pharmaceutical composition that modulates the function of the C-RET receptor.

摘要翻译： 本发明部分地涉及一种预防或治疗由C-RET受体的功能异常引起的异常状况的方法，特别涉及治疗和预防神经变性疾病的方法，该方法是通过施用调节功能的药物组合物 C-RET受体。