公开(公告)号：US06638916B1

公开(公告)日：2003-10-28

申请号：US09486617

申请日：2000-05-09

申请人： William B. Cowden ,  Douglas J. Francis ,  Christopher R. Parish

发明人： William B. Cowden ,  Douglas J. Francis ,  Christopher R. Parish

IPC分类号： A61K31715

CPC分类号： A61K31/7024 ,  A61K31/737

摘要： A method for the inhibition of vascular smooth muscle cell hyperplasia in a human or other warm-blooded animal patient in need of such treatment, comprises administration to the patient of an effective amount of at least one sulfated oligosaccharide, wherein the oligosaccharide has the general formula I: R1—(Rx)n—R2  (I) wherein R1 and R2 and each Rx represents a monosaccharide unit, all of which may be the same or different, adjacent monosaccharide units being linked by 1→2, 1→3, 1→4 and/or 1→6 glycosidic bonds and n is an integer of from 1 to 6.

摘要翻译： 在需要这种治疗的人或其他温血动物患者中抑制血管平滑肌细胞增生的方法包括向患者施用有效量的至少一种硫酸化寡糖，其中寡糖具有通式 I：其中R1和R2和每个Rx代表单糖单元，它们都可以相同或不同，相邻的单糖单元通过1-> 2,1-3，1-> 4和/或1-> 6糖苷键，n为1至6的整数。