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1.Identification of the domain of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) that mediates adhesion to chondroitin sulfate A 失效
标题翻译: 鉴定恶性疟原虫红细胞膜蛋白1(PfEMP1)的结构域,其介导对硫酸软骨素A的粘附公开(公告)号:US06855323B2
公开(公告)日:2005-02-15
申请号:US10087013
申请日:2002-02-21
申请人: Artur Scherf , Louis H. Miller , Benoit Gamain , Dror I. Baruch , Pierre Buffet , Christine Scheidig , Jurg Gysin , Bruno Pouvelle , Nobutaka Fujii , Joseph Smith
发明人: Artur Scherf , Louis H. Miller , Benoit Gamain , Dror I. Baruch , Pierre Buffet , Christine Scheidig , Jurg Gysin , Bruno Pouvelle , Nobutaka Fujii , Joseph Smith
IPC分类号: A61K38/00 , A61K39/00 , A61K48/00 , C07K14/445 , C12N15/30 , C12Q1/68 , G01N33/569 , A61K39/015 , A61K39/002 , C07K14/00
CPC分类号: C07K14/445 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/505 , A61K2039/53 , C12Q1/6883 , C12Q2600/158 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要: The present invention relates to the discovery of a var gene and corresponding protein that modulates adhesion of parasitized red blood cells to chondroitin sulfate A. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
摘要翻译: 本发明涉及一种调节寄生红细胞粘附到硫酸软骨素A上的var基因和相应蛋白质的发现。还公开了上述的新型生物工具,预防,治疗,诊断和使用方法。