公开(公告)号：US20110245537A1

公开(公告)日：2011-10-06

申请号：US13134607

申请日：2011-06-09

申请人： Xueliang Yuan ,  Guoqing Mei ,  Duqing Qing ,  Weiwei Zhang ,  Ling Chen

发明人： Xueliang Yuan ,  Guoqing Mei ,  Duqing Qing ,  Weiwei Zhang ,  Ling Chen

IPC分类号： C07C227/14

CPC分类号： C07C227/16 ,  C07C229/22

摘要： L-carnitine calcium fumarate and its preparation and applications are disclosed in the present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the L-carnitine calcium fumarate as proposed having the advantages of being non-hygroscopic, stable in chemical property, and suitable for oral administration. A preparing method is as follow: fumaric acid is suspended in water and calcium base is added. The resulting mixture is heated up to 70˜90° C. and kept under stirring for 2˜8 hours, and then concentrated under reduced pressure. The resulting dried substance is added into ethanol, and the mixture is vigorously stirred. The inner salt of L-carnitine is added, and the mixture is reacted for 1˜6 hours at 60˜70° C. and then cooled for 2˜8 hours. L-carnitine calcium fumarate is obtained by filtration.

摘要翻译： L-肉碱富马酸钙及其制备和应用在本发明中公开。 具有良好的水溶性以及比相应的内盐更好和更强的营养和处理功能，所提出的L-肉碱富马酸钙具有非吸湿性，化学性质稳定并且适合于口服给药的优点。 制备方法如下：将富马酸悬浮于水中，加入钙碱。 将所得混合物加热至70〜90℃，并保持搅拌2〜8小时，然后减压浓缩。 将所得干物质加入到乙醇中，并将混合物剧烈搅拌。 加入左旋肉碱的内盐，混合物在60〜70℃下反应1〜6小时，然后冷却2〜8小时。 通过过滤获得L-肉碱富马酸钙。

公开(公告)号：US20090281183A1

公开(公告)日：2009-11-12

申请号：US12310192

申请日：2007-10-19

申请人： Xueliang Yuan ,  Guoqing Mei ,  Duqing Qing ,  Weiwei Zhang ,  Ling Chen

发明人： Xueliang Yuan ,  Guoqing Mei ,  Duqing Qing ,  Weiwei Zhang ,  Ling Chen

IPC分类号： A61K31/205 ,  C07C57/15 ,  A61P9/10

CPC分类号： C07C229/22 ,  A23K20/105 ,  A23K20/147 ,  A23K20/24 ,  A23L33/175 ,  A23V2002/00 ,  C07C57/15 ,  A23V2200/30 ,  A23V2200/326 ,  A23V2250/0612 ,  A23V2250/036 ,  A23V2250/1578

摘要： L-carnitine calcium fumarate and its preparation and applications are disclosed in the present invention. Having good water solubility as well as better and stronger nutritious and treating functions than the corresponding inner salts, the L-carnitine calcium fumarate as proposed having the advantages of being non-hygroscopic, stable in chemical property, and suitable for oral administration. A preparing method is as follow: fumaric acid is suspended in water and calcium base is added. The resulting mixture is heated up to 70˜90° C. and kept under stirring for 2˜8 hours, and then concentrated under reduced pressure. The resulting dried substance is added into ethanol, and the mixture is vigorously stirred. The inner salt of L-carnitine is added, and the mixture is reacted for 1-6 hours at 60˜70° C. and then cooled for 2˜8 hours. L-carnitine calcium fumarate is obtained by filtration.

摘要翻译： L-肉碱富马酸钙及其制备和应用在本发明中公开。 具有良好的水溶性以及比相应的内盐更好和更强的营养和处理功能，所提出的L-肉碱富马酸钙具有非吸湿性，化学性质稳定并且适合于口服给药的优点。 制备方法如下：将富马酸悬浮于水中，加入钙碱。 将所得混合物加热至70〜90℃，并保持搅拌2〜8小时，然后减压浓缩。 将所得干物质加入到乙醇中，并将混合物剧烈搅拌。 加入左旋肉碱的内盐，混合物在60〜70℃下反应1-6小时，然后冷却2〜8小时。 通过过滤获得L-肉碱富马酸钙。