公开(公告)号：US5750552A

公开(公告)日：1998-05-12

申请号：US622469

申请日：1996-03-25

申请人： Eitaro Arakawa ,  Tetsuo Kato ,  Tsukasa Takamura ,  Keiji Imai ,  Tetsuya Segami ,  Yukitaka Nakamura

发明人： Eitaro Arakawa ,  Tetsuo Kato ,  Tsukasa Takamura ,  Keiji Imai ,  Tetsuya Segami ,  Yukitaka Nakamura

IPC分类号： A61K31/415 ,  A61K31/4164 ,  A61P1/04 ,  A61P17/02 ,  A61P43/00 ,  C07D233/84 ,  C07D401/12

CPC分类号： C07D401/12 ,  C07D233/84

摘要： An imidazoline derivative or possible tautomer thereof, represented by the formula (1), wherein n represents one of integers "1" through "4", and R.sub.1 and R.sub.2 represent hydrogen atom, lower alkyl, aryl, aralkyl group, or R.sub.1 and R.sub.2 cooperate to represent alkylene, alkylidene or arylalkylidene group, while R.sub.3 represents a nitrogen-containing aromatic ring that may be substituted by lower alkyl, alkoxy or alkanoyl group, or a substituted phenyl group represented by the formula (2), wherein R.sub.4 and R.sub.5 represent hydrogen atom, lower alkyl group that may be substituted by halogen atom or hydroxyl group, cycloalkylalkyl group, lower alkenyl group, lower alkanoyl group that may be substituted by halogen atom, lower alkoxyalkyl or alkoxycarbonyl group, arylcarbonyl, arylalkyl or arylalkoxycarbonyl group, lower alkylaminocarbonyl or alkylsulfonyl group or arylsulfonyl group, or R.sub.4 and R.sub.5 cooperate with an adjacent nitrogen atom to constitute a cyclic structure, while R.sub.6 represents hydrogen atom, hydroxyl group, halogen atom, lower alkyl or alkoxy group or nitro group. ##STR1##

摘要翻译： 由式（1）表示的咪唑啉衍生物或其可能的互变异构体，其中n表示整数“1”至“4”中的一个，R1和R2表示氢原子，低级烷基，芳基，芳烷基或R1和R2 合成表示亚烷基，亚烷基或芳烷基，而R3表示可被低级烷基，烷氧基或烷酰基取代的含氮芳香环或由式（2）表示的取代苯基，其中R4和R5代表 氢原子，可以被卤素原子或羟基取代的低级烷基，环烷基烷基，低级烯基，可被卤素原子取代的低级烷酰基，低级烷氧基烷基或烷氧基羰基，芳基羰基，芳基烷基或芳基烷氧基羰基，低级烷基氨基羰基 或烷基磺酰基或芳基磺酰基，或者R 4和R 5与相邻的氮原子配位以构成环状结构，而R6代表氢原子，氢 甲酰基，卤素原子，低级烷基或烷氧基或硝基。 （1）（2）

公开(公告)号：US5733922A

公开(公告)日：1998-03-31

申请号：US603232

申请日：1996-02-20

申请人： Eitaro Arakawa ,  Tetsuo Kato ,  Tsukasa Takamura ,  Keiji Imai ,  Tetsuya Segami ,  Yukitaka Nakamura

发明人： Eitaro Arakawa ,  Tetsuo Kato ,  Tsukasa Takamura ,  Keiji Imai ,  Tetsuya Segami ,  Yukitaka Nakamura

IPC分类号： A61K31/415 ,  A61K31/4166 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/47 ,  A61P1/04 ,  C07D233/84 ,  C07D233/86 ,  C07D233/96 ,  C07D401/12 ,  C07D401/14 ,  C07D233/42

CPC分类号： C07D401/12 ,  C07D233/84 ,  C07D233/86 ,  C07D401/14

摘要： An imidazole derivative represented by one of formulas (1), wherein R.sub.1, R.sub.2 represents hydrogen atom, lower alkyl, aryl, aralkyl group, or R.sub.1 and R.sub.2 cooperate to represent alkylene, alkylidene, arylalkylidene group, R.sub.3 representing hydrogen atom, lower alkyl or alkanoyl group, or aralkyl or arylcarbonyl group, wherein at least one of A and B represents a group represented by formula (2), wherein m represents an integer 1-4, R.sub.4 representing nitrogen-containing aromatic ring that may be substituted by lower alkyl, alkoxy or alkanoyl group, or phenyl group represented by formula (3), R.sub.5, R.sub.6 representing hydrogen atom, lower alkyl or alkenyl group, or lower alkanoyl or arylcarbonyl group which may be substituted by a halogen atom, R.sub.7 representing hydrogen or halogen atom, hydroxyl or nitro group, or lower alkyl or alkoxy group, wherein the other of A and B represents oxygen or sulfur atom, hydroxyl, mercapto, alkylthio, alkenylthio or aralkylthio group, or group represented by the formula (2), ##STR1##

摘要翻译： 由式（1）之一表示的咪唑衍生物，其中R 1，R 2表示氢原子，低级烷基，芳基，芳烷基或R 1和R 2表示亚烷基，亚烷基，芳基亚烷基，R 3表示氢原子，低级烷基或 烷酰基或芳烷基或芳基羰基，其中A和B中的至少一个表示由式（2）表示的基团，其中m表示1-4的整数，R4代表可被低级烷基取代的含氮芳香环 ，烷氧基或烷酰基，或由式（3）表示的苯基，R5，R6代表氢原子，低级烷基或烯基，或可被卤素原子取代的低级烷酰基或芳基羰基，R7代表氢或卤素原子 ，羟基或硝基，或低级烷基或烷氧基，其中A和B中的另一个表示氧或硫原子，羟基，巯基，烷硫基，烯硫基或芳烷硫基，或由式 （1） S（CH2）mR4（2）（3）