公开(公告)号：US20250074983A1

公开(公告)日：2025-03-06

申请号：US18554213

申请日：2022-04-04

Applicant: Mallika LALA ,  Carolina DE MIRANDA SILVA ,  Ferdous GHEYAS ,  Yogita KRISHNA MACHARI ,  Elliot Keith CHARTASH ,  Lokesh JAIN ,  Venkata Naga Ratna Pavan Kumar VADDADY ,  MERCK SHARP & DOHME LLC

Inventor： Mallika LALA ,  Carolina DE MIRANDA SILVA ,  Ferdous GHEYAS ,  Yogita KRISHNAMACHARI ,  Elliot Keith CHARTASH ,  Lokesh JAIN ,  Venkata Naga Ratna Pavan Kumar VADDADY

IPC: C07K16/28

Abstract: The invention relates to methods for treating cancer in a patient comprising subcutaneously administering a PD-1 antagonist, e.g., an anti-PD-1 antibody, or antigen binding fragment thereof, (e.g. pembrolizumab), in specific amounts to the patient. In some embodiments, the administration occurs about every three weeks. In some embodiments, the amount of anti-PD-1 antibody, or antigen binding fragment thereof, is about 280 mg to about 450 mg. In certain embodiments, the PD-1 antagonist is pembrolizumab, or an antigen binding fragment thereof. Also provided are compositions and kits formulated for subcutaneous administration comprising a dosage of an anti-PD-1 antibody, or antigen-binding fragment thereof, and uses thereof for treating cancer.

公开(公告)号：US20180161427A1

公开(公告)日：2018-06-14

申请号：US15577377

申请日：2016-05-26

Applicant: Ying YU ,  Elliot Keith CHARTASH ,  Svetlana SADEKOVA ,  Uyen Truong PHAN ,  Robert A. KASTELEIN ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI ,  Robert S. JANSSEN ,  MERCK SHARP & DOHME CORP. ,  DYNAVAX TECHNOLOGIES CORPORATION

Inventor： Ying YU ,  Elliot Keith CHARTASH ,  Svetlana SADEKOVA ,  Uyen Truong PHAN ,  Robert A. KASTELEIN ,  Robert L. COFFMAN ,  Cristiana GUIDUCCI ,  Robert S. JANSSEN

IPC: A61K39/395 ,  A61K31/7125 ,  A61P35/00

CPC classification number: A61K39/3955 ,  A61K31/7125 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55561 ,  A61P35/00 ,  C07K16/244

Abstract: The present disclosure describes combination therapies comprising an anti-IL-10 antibody or antigen-binding fragment thereof and a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.

公开(公告)号：US09051368B2

公开(公告)日：2015-06-09

申请号：US12813303

申请日：2010-06-10

Applicant: Elliot Keith Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Joaquin M. Valdes ,  Alexandra B. Kimball

Inventor： Elliot Keith Chartash ,  William T. Barchuk ,  Susan K. Paulson ,  Joaquin M. Valdes ,  Alexandra B. Kimball

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  Y10S514/885 ,  Y10S514/886

Abstract: The invention provides a method of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

Abstract translation: 本发明提供了通过向受试者施用能够结合IL-12和/或IL-23的p40亚基的抗体来治疗受试者中的牛皮癣的方法。

公开(公告)号：US20130243763A1

公开(公告)日：2013-09-19

申请号：US13903525

申请日：2013-05-28

Applicant: Subhashis Banerjee ,  Lori K. Taylor ,  Clive E. Spiegler ,  Daniel Edward Tracey ,  Elliot Keith Chartash ,  Rebecca S. Hoffman ,  William T. Barchuk ,  Philip Yan ,  Anwar Murtaza ,  Jochen G. Salfeld ,  Steven A. Fischkoff

Inventor： Subhashis Banerjee ,  Lori K. Taylor ,  Clive E. Spiegler ,  Daniel Edward Tracey ,  Elliot Keith Chartash ,  Rebecca S. Hoffman ,  William T. Barchuk ,  Philip Yan ,  Anwar Murtaza ,  Jochen G. Salfeld ,  Steven A. Fischkoff

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/388 ,  Y02A50/412

Abstract: Methods of treating TNFα-related disorders comprising administering TNFα inhibitors, including TNFα antibodies are described.

Abstract translation: 描述了治疗TNFalpha相关病症的方法，包括给予TNFα抑制剂，包括TNFα抗体。