公开(公告)号：US20110142953A1

公开(公告)日：2011-06-16

申请号：US13025347

申请日：2011-02-11

申请人： Hendrik J. SCHUURMAN ,  Emanuele Luigi COZZI ,  Francoise RICHARD ,  Guy TACCARD ,  David James Graham WHITE ,  Peter John FRIEND ,  John WALLWORK ,  Paolo BRENNER

发明人： Hendrik J. SCHUURMAN ,  Emanuele Luigi COZZI ,  Francoise RICHARD ,  Guy TACCARD ,  David James Graham WHITE ,  Peter John FRIEND ,  John WALLWORK ,  Paolo BRENNER

IPC分类号： A61K38/13 ,  A61P37/06

CPC分类号： A61K38/13 ,  A61K31/00 ,  A61K31/365 ,  A61K31/4745 ,  A61K2300/00

摘要： A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2 transcription inhibitor and immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts, and pharmaceutically acceptable diluents or carriers, and a method of preventing hyperacute rejection, reducing early graft damage, improving early xenograft function and promoting long term survival of said transgenic xenografts comprising the steps of i) contacting the body fluid removed from a human recipient with a xenoantigenic material which is bound to a biocompatible solid support, ii) reintroducing the treated body fluid into the recipient, and iii) treating the recipient with said pharmaceutical composition.

摘要翻译： 一种可用于治疗或预防转基因异种移植排斥的药物组合物，其包含免疫抑制剂化合物，其选自由免疫抑制异种移植物B细胞介导或抗体介导的排斥反应的IL-2转录抑制剂和免疫抑制剂化合物，以及药学上可接受的 稀释剂或载体，以及预防超急性排斥反应，减少早期移植物损伤，改善早期异种移植物功能并促进所述转基因异种移植物的长期存活的方法，包括以下步骤：i）将从人接受者移除的体液与异种抗生素材料接触， 与生物相容的固体支持物结合，ii）将经处理的体液重新引入受体中，和iii）用所述药物组合物治疗接受者。

公开(公告)号：US20080199478A1

公开(公告)日：2008-08-21

申请号：US12109210

申请日：2008-04-24

申请人： Hendrik J. SCHUURMAN ,  Emanuele Luigi Cozzi ,  Francoise Richard ,  Guy Taccard ,  David James Graham White ,  Peter John Friend ,  John Wallwork ,  Paolo Brenner

发明人： Hendrik J. SCHUURMAN ,  Emanuele Luigi Cozzi ,  Francoise Richard ,  Guy Taccard ,  David James Graham White ,  Peter John Friend ,  John Wallwork ,  Paolo Brenner

IPC分类号： A61K38/13 ,  A61K39/395 ,  A61P43/00

CPC分类号： A61K38/13 ,  A61K31/00 ,  A61K31/365 ,  A61K31/4745 ,  A61K2300/00

摘要： A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2 transcription inhibitor and immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts, and pharmaceutically acceptable diluents or carriers, and a method of preventing hyperacute rejection, reducing early graft damage, improving early xenograft function and promoting long term survival of said transgenic xenografts comprising the steps of i) contacting the body fluid removed from a human recipient with a xenoantigenic material which is bound to a biocompatible solid support, ii) reintroducing the treated body fluid into the recipient, and iii) treating the recipient with said pharmaceutical composition.

摘要翻译： 一种可用于治疗或预防转基因异种移植排斥的药物组合物，其包含免疫抑制剂化合物，其选自由免疫抑制异种移植物B细胞介导或抗体介导的排斥反应的IL-2转录抑制剂和免疫抑制剂化合物，以及药学上可接受的 稀释剂或载体，以及预防超急性排斥反应，减少早期移植物损伤，改善早期异种移植物功能并促进所述转基因异种移植物的长期存活的方法，包括以下步骤：i）将从人接受者移除的体液与异种抗生素材料接触， 与生物相容的固体支持物结合，ii）将经处理的体液重新引入受体中，和iii）用所述药物组合物治疗接受者。