公开(公告)号：US20110044895A1

公开(公告)日：2011-02-24

申请号：US12852973

申请日：2010-08-09

Applicant: David A. Berry ,  Eric J. Devroe ,  Noubar B. Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

Inventor： David A. Berry ,  Eric J. Devroe ,  Noubar B. Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

IPC: A61K51/00 ,  C12N5/09 ,  A61K39/395 ,  A61K31/7105 ,  A61K49/00 ,  C12N5/095 ,  A61K31/7088 ,  A61P35/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/713 ,  A61K2300/00

Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.

Abstract translation: 本发明提供了用于减少分化细胞（例如癌细胞）和癌干细胞的混合群体中的癌干细胞数目的方法和组合物。 癌症干细胞（如果存在）可以更好地抵抗传统的基于药物的疗法，并且可以为与耐药性和更具侵袭性的表型的发展相关联的新的分化癌细胞提供来源。 当与传统的癌症疗法结合时，例如基于药物的疗法，本发明的方法和组合提供了治疗癌症的更有效的方法，并且可以提供用于开发新的癌症疗法和新的治疗方式的模型系统。

公开(公告)号：US20090047295A1

公开(公告)日：2009-02-19

申请号：US12171923

申请日：2008-07-11

Applicant: David A. Berry ,  Eric J. Devroe ,  Noubar Boghos Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

Inventor： David A. Berry ,  Eric J. Devroe ,  Noubar Boghos Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

IPC: A61K39/395 ,  C12N5/08 ,  A61K31/7105 ,  A61P31/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/713 ,  A61K2300/00

Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.

Abstract translation: 本发明提供了用于减少分化细胞（例如癌细胞）和癌干细胞的混合群体中的癌干细胞数目的方法和组合物。 癌症干细胞（如果存在）可以更好地抵抗传统的基于药物的疗法，并且可以为与耐药性和更具侵袭性的表型的发展相关联的新的分化癌细胞提供来源。 当与传统的癌症疗法结合时，例如基于药物的疗法，本发明的方法和组合提供了治疗癌症的更有效的方法，并且可以提供用于开发新的癌症疗法和新的治疗方式的模型系统。