公开(公告)号：US20100227671A1

公开(公告)日：2010-09-09

申请号：US12475025

申请日：2009-05-29

申请人： Mohamed Laaroussi ,  Hugues Boisvert ,  Eric Levesque

发明人： Mohamed Laaroussi ,  Hugues Boisvert ,  Eric Levesque

IPC分类号： A63F9/24 ,  G06F12/00 ,  G06F13/38 ,  G06Q40/00

CPC分类号： G07F17/3244 ,  G06Q40/12 ,  G07F17/32 ,  G07F17/3223 ,  G07F17/3232

摘要： A currency media reader hub on a gaming machine to monitor transactions is provided. The currency media reader hub comprises a communication board module comprising a communication port module adapted to connect the currency media reader hub with a peripheral component, a network port module adapted to connect the currency media reader hub to a network, a currency media reader module connected to the communication board module, the currency media reader module being adapted to communicate with a virtual currency holding media and transfer data between the communication board module and the virtual currency holding media, a user interface module connected to the communication board and adapted to display a currency value stored on the virtual currency holding media and an intelligent board module connected to the communication board to provide communication capability with the network.

摘要翻译： 提供了一种用于监控交易的游戏机上的货币媒体读取器集线器。 货币媒体读取器集线器包括通信板模块，其包括适于将货币媒体读取器集线器与外围组件连接的通信端口模块，适于将货币媒体读取器集线器连接到网络的网络端口模块，连接的货币媒体读取器模块 所述货币媒体读取器模块适于与所述虚拟货币保持媒体进行通信，并且在所述通信板模块和所述虚拟货币持有媒体之间传送数据;连接到所述通信板的用户界面模块， 存储在虚拟货币持有媒体上的货币值和连接到通信板的智能板模块，以提供与网络的通信能力。

公开(公告)号：US06287834B1

公开(公告)日：2001-09-11

申请号：US09180852

申请日：1999-02-08

申请人： Alain Belanger ,  Dean W. Hum ,  Martin Beaulieu ,  Eric Levesque

发明人： Alain Belanger ,  Dean W. Hum ,  Martin Beaulieu ,  Eric Levesque

IPC分类号： C12P2106

CPC分类号： C12N9/1051 ,  A61K38/00 ,  A61K48/00

摘要： A uridine diphospho-glucuronosyltransferase (UGTB217) is provided. Methods of producing the enzyme and using the enzyme to identify potential compounds which inhibit or alter the activity of the enzyme are described. In addition, methods of using antibodies to localize the protein, or using the gene sequence or portions thereof for probes or using the gene sequence to produce expression-disrupting sense or antisense DNA fragments thereof, or antisense RNA, are provided.

摘要翻译： 提供尿苷二磷酸 - 葡萄糖醛酸基转移酶（UGTB217）。 描述了生产酶并使用该酶鉴定抑制或改变酶的活性的潜在化合物的方法。 此外，提供了使用抗体来定位蛋白质的方法，或者使用基因序列或其部分用于探针或使用基因序列产生表达破坏其有义或反义DNA片段或反义RNA的方法。

公开(公告)号：US06234318B1

公开(公告)日：2001-05-22

申请号：US09305787

申请日：1999-05-04

申请人： Yves Breau ,  Martin DeMontigny ,  Eric Levesque ,  Jacques McMullen ,  Dany Pelletier ,  Pierre Pelletier

发明人： Yves Breau ,  Martin DeMontigny ,  Eric Levesque ,  Jacques McMullen ,  Dany Pelletier ,  Pierre Pelletier

IPC分类号： B03D102

CPC分类号： C22B11/08 ,  B03D1/02 ,  B03D1/028 ,  B03D1/14

摘要： A method for controlling a froth flotation system in a mineral processing operation for recovering metal from a metal source. A rule-based expert system adjusts performance of the froth flotation system.

摘要翻译： 一种用于在矿物处理操作中控制泡沫浮选系统以从金属源回收金属的方法。 基于规则的专家系统调整泡沫浮选系统的性能。

公开(公告)号：US20130149703A1

公开(公告)日：2013-06-13

申请号：US13701163

申请日：2011-05-31

申请人： Eric Levesque ,  Chantal Guillemette ,  Yves Fradet ,  Louis Lacombe

发明人： Eric Levesque ,  Chantal Guillemette ,  Yves Fradet ,  Louis Lacombe

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Purpose. The relationship between inherited genetic variations in 5α-reductase type 1 (SRD5A1) and type 2 (SRD5A2) genes and the risk of biochemical recurrence after radical prostatectomy (RP) in prostate cancer (PCa) remains a fairly unexplored area of research. Patients and Methods. We studied 526 men with organ-confined and locally advanced PCa with a median follow-up time of 7.4 years. We investigated the effects of allelic variants of SRD5A1 and SRD5A2 genes and haplotype-tagging single nucleotide polymorphisms (htSNPs; n=19) on recurrence-free survival after RP using Kaplan-Meier plots, the log-rank test, and Cox proportional hazard models. Results. Upon adjusting for known prognostic clinical and pathological factors, eight htSNPs were shown to be independent predictors of recurrence. The SRD5A1 rs166050 polymorphism was associated with an increased recurrence risk of HR=1.83 (95% CI, 1.04-3.21; P=0.035), while the rs518673 in SRD5A1 was associated with a decreased risk (HR=0.59, 95% CI, 0.41-0.85; P=0.004). The SRD5A2 gene was strongly associated with the risk of relapse with six polymorphisms being positively associated with recurrence including the known SRD5A2 V89L (rs523349) (HR=2.14, 95% CI, 1.23-3.70; P=0.007) and a protective htSNP rs12470143 with a HR of 0.66, (95% CI, 0.46-0.95; P=0.023). By combining SRD5A1 (rs518673T) and SRD5A2 (rs12470143 A), the protective effect was shown to be additive with the maximum protection conferred by 3 or 4 alleles (HR=0.33, 95% CL 0.17-0.63; P=0.001). Conclusion. Germline polymorphisms in 5α-reductase genes are independent prognostic genetic biomarkers that predict PCa biochemical recurrence after radical prostatectomy and may represent useful molecular tools for a genotype-tailored clinical approach.

摘要翻译： 目的。 5α-还原酶1型（SRD5A1）和2型（SRD5A2）基因遗传遗传变异与前列腺癌（PCa）根治性前列腺切除术（RP）后生化复发的风险之间的关系仍然是一个尚未开发的研究领域。 患者和方法 我们研究了526名患有器官限制和局部晚期PCa的男性，中位随访时间为7.4年。 我们调查了使用Kaplan-Meier图，对数秩检验和Cox比例风险模型，SRD5A1和SRD5A2基因的等位基因变体和单倍型标记单核苷酸多态性（htSNPs; n = 19）对无复发生存率的影响 。 结果。 在调整已知的预后临床和病理因素后，8个htSNPs显示为复发的独立预测因子。 SRD5A1 rs166​​050多态性与HR = 1.83（95％CI，1.04-3.21; P = 0.035）复发风险增加相关，SRD5A1 rs518673与风险降低有关（HR = 0.59,95％CI，0.41 -0.85; P = 0.004）。 SRD5A2基因与复发风险强烈相关，其中6个多态性与复发呈正相关，包括已知的SRD5A2 V89L（rs523349）（HR = 2.14,95％CI，1.23-3.70; P = 0.007）和保护性htSNP rs12470143与 HR为0.66（95％CI，0.46-0.95; P = 0.023）。 通过组合SRD5A1（rs518673T）和SRD5A2（rs12470143A），保护作用显示为3或4等位基因赋予的最大保护（HR = 0.33,95％CL 0.17-0.63; P = 0.001）。 结论。 5α-还原酶基因中的种系多态性是独立的预后遗传生物标志物，其预测根治性前列腺切除术后的PCa生化复发，并且可能代表基因型定制临床方法的有用的分子工具。