公开(公告)号：US07022475B2

公开(公告)日：2006-04-04

申请号：US09974619

申请日：2001-10-10

申请人： Erin Schuetz ,  Jiong Zhang ,  Mahfoud Assem

发明人： Erin Schuetz ,  Jiong Zhang ,  Mahfoud Assem

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  Y02A90/26

摘要： Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying subjects having a low or high drug metabolizing phenotype associated with CYP3A5 expression are provided. Assays, kits and methods for determining and assaying the CYP3A5 genotype and phenotype of individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's metabolism of drugs and therapeutic agents, the potential for drug interactions, and thereby toxicity and effectiveness of certain drugs and treatment modalities, are provided.

公开(公告)号：US20060110767A1

公开(公告)日：2006-05-25

申请号：US11285364

申请日：2005-11-22

申请人： Erin Schuetz ,  Jiong Zhang ,  Mahfoud Assem

发明人： Erin Schuetz ,  Jiong Zhang ,  Mahfoud Assem

IPC分类号： C12Q1/68 ,  G06F19/00 ,  C12P19/34

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  Y02A90/26

摘要： Genetic polymorphisms responsible or associated with altered expression of cytochrome P450 CYP3A5 enzyme are described. Single nucleotide polymorphisms are provided. Methods for identifying subjects having a low or high drug metabolizing phenotype associated with CYP3A5 expression are provided. Assays, kits and methods for determining and assaying the CYP3A5 genotype and phenotype of individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods for determining and evaluating an individual's metabolism of drugs and therapeutic agents, the potential for drug interactions, and thereby toxicity and effectiveness of certain drugs and treatment modalities, are provided.

摘要翻译： 描述了负责或与细胞色素P450 CYP3A5酶表达改变相关的遗传多态性。 提供单核苷酸多态性。 提供了用于鉴定与CYP3A5表达相关的低或高药物代谢表型的受试者的方法。 公开了用于确定和测定个体患者的CYP3A5基因型和表型的测定，试剂盒和方法。 描述了用于测定，试剂盒和方法的寡核苷酸探针和引物。 提供了用于确定和评估个体的药物和治疗剂代谢的药物相互作用的可能性，以及某些药物和治疗方式的毒性和有效性的测定和方法。