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    PROCESS OF PREPARING MICROSPHERES FOR SUSTAINED RELEASE HAVING IMPROVED DISPERSIBILITY AND SYRINGEABILITY
    1.
    发明申请
    PROCESS OF PREPARING MICROSPHERES FOR SUSTAINED RELEASE HAVING IMPROVED DISPERSIBILITY AND SYRINGEABILITY 有权
    制备具有改善的可分散性和可发性的持续释放微生物的方法

    公开(公告)号：US20090269414A1

    公开(公告)日：2009-10-29

    申请号：US12429523

    申请日：2009-04-24

    申请人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Seol ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi ,  Ju-Han Lee

    发明人： Hee-Yong Lee ,  Jung-Soo Kim ,  Eun-Ho Shin ,  Seong-Kyu Kim ,  Eun-Young Seol ,  Mi-Jin Baek ,  Mi-Young Baek ,  Yeon-Jin Chae ,  Ho-Il Choi ,  Ju-Han Lee

    IPC分类号： A61K9/52 ,  A61P43/00

    CPC分类号： A61K9/1647 ,  A61K9/1635 ,  A61K9/1694 ,  A61K31/765 ,  A61K38/09 ,  A61K38/31

    摘要： Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.

    摘要翻译： 公开了一种使用喷雾干燥制备含有可生物降解的聚合物作为载体和药物的缓释微球的方法。 该方法包括制备含有可生物降解的聚合物，药物和溶剂的溶液，悬浮液或乳液; 喷雾干燥溶液，悬浮液或乳液; 并将喷雾干燥的微球悬浮在含有聚乙烯醇的水溶液中以除去残留溶剂并增加微球表面的亲水性。 该方法能够制备具有高药物包封效率的微球，由于残留溶剂几乎不具有毒性问题，并且具有良好的可注射性。 根据本发明制备的微球体在施用于身体时以持续的方式释放药物的有效浓度达预定时间，因此可用于治疗疾病。

    COMPOSITION AND MICROSPHERE FOR CONTROLLED-RELEASE OF EXENDIN, AND METHOD OF PREPARING THE SAME
    4.
    发明申请
    COMPOSITION AND MICROSPHERE FOR CONTROLLED-RELEASE OF EXENDIN, AND METHOD OF PREPARING THE SAME 有权
    用于控制释放exendin的组合物和微球及其制备方法

    公开(公告)号：US20100136126A1

    公开(公告)日：2010-06-03

    申请号：US12532311

    申请日：2008-01-22

    申请人： Hee-Yong Lee ,  Eun-Young Seol ,  Joon-Sik Kim ,  Mi-Jin Baek ,  Jung-Soo Kim ,  Ju-Han Lee ,  Yeon-Jin Chae ,  Chae-Jin Lim ,  Mi-Young Baek ,  Ho-Il Choi

    发明人： Hee-Yong Lee ,  Eun-Young Seol ,  Joon-Sik Kim ,  Mi-Jin Baek ,  Jung-Soo Kim ,  Ju-Han Lee ,  Yeon-Jin Chae ,  Chae-Jin Lim ,  Mi-Young Baek ,  Ho-Il Choi

    IPC分类号： A61K38/16 ,  A61K9/14 ,  A61P3/10

    CPC分类号： A61K9/1647 ,  A61K9/0024 ,  A61K9/19 ,  A61K9/5015 ,  A61K9/5026 ,  A61K38/2278 ,  A61K47/26 ,  A61K47/38

    摘要： A controlled-release composition and controlled-release microspheres containing an exendin as an active ingredient, and a method of preparing the same are provided. More specifically, a controlled-release composition containing an exendin as an active ingredient, a biodegradable polymer with a specific viscosity, and coating materials, having high bioavailability and showing sustained release of the active ingredient in an effective concentration for a certain period without an excessive initial burst of the active ingredient; controlled-release microspheres containing a core including an exendin as an active ingredient and a biodegradable polymer, and a coating layer coating the core; and a method of preparing controlled-release microspheres including the steps of mixing an exendin, a biodegradable polymer, and a solvent, removing the solvent from the mixture to prepare hardened microspheres, and coating the hardened microspheres to form a coating layer on the surface of each microsphere, are provided.

    摘要翻译： 提供含有毒蜥外泌肽作为活性成分的控释组合物和控释微球及其制备方法。 更具体地说，含有毒蜥外泌肽作为活性成分的控释组合物，具有特定粘度的可生物降解的聚合物和具有高生物利用度的涂层材料，并显示有效浓度的有效成分在一定时间内持续释放而不会过度 初步爆发的活性成分; 含有包含毒蜥外泌肽作为活性成分的核心和可生物降解的聚合物的控释微球，以及涂覆该芯的涂层; 以及制备控释微球的方法，包括以下步骤：混合毒蜥外泌素，可生物降解的聚合物和溶剂，从混合物中除去溶剂以制备硬化的微球，并涂覆硬化的微球，以在 提供每个微球。