专利检索 ap:"Ewald T.J. Van Den Bremer" 第 1 页

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发明申请
MODULATION OF COMPLEMENT-DEPENDENT CYTOTOXICITY THROUGH MODIFICATIONS OF THE C-TERMINUS OF ANTIBODY HEAVY CHAINS 审中-公开
标题翻译：通过抗体重链C末端修饰来补充依赖性细胞毒性的调节

公开(公告)号：US20140271623A1

公开(公告)日：2014-09-18

申请号：US14130580

申请日：2012-07-06

申请人： Paul Parren , Patrick Van Berkel , Ewald T.J. Van Den Bremer

发明人： Paul Parren , Patrick Van Berkel , Ewald T.J. Van Den Bremer

IPC分类号： C07K16/18 , G01N33/50 , G01N33/68

CPC分类号： C07K16/18 , C07K16/00 , C07K2317/51 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/734 , G01N33/5014 , G01N33/6854

摘要： Antibody variants having decreased or increased ability to mediate CDC due to modifications at the C-terminus of their heavy chains are described. Methods of generating such antibodies, as well as nucleotide constructs and host cells suitable for the production of said antibodies are also described.

摘要翻译： 描述了由于其重链C末端的修饰而具有降低或增加的CDC介导的CDC的抗体变体。还描述了产生这种抗体的方法，以及适用于产生所述抗体的核苷酸构建体和宿主细胞。