公开(公告)号：US07371383B2

公开(公告)日：2008-05-13

申请号：US10412703

申请日：2003-04-11

申请人： Jennifer Lynne Reed ,  William Dall'Acqua ,  Jacques Van Snick ,  Jean-Christophe Renauld ,  Francoise Cormont ,  Catherine Uyttenhove

发明人： Jennifer Lynne Reed ,  William Dall'Acqua ,  Jacques Van Snick ,  Jean-Christophe Renauld ,  Francoise Cormont ,  Catherine Uyttenhove

IPC分类号： A61K39/395

CPC分类号： C07K16/244 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.

摘要翻译： 本申请描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用于预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。

公开(公告)号：US20080299134A1

公开(公告)日：2008-12-04

申请号：US12049566

申请日：2008-03-17

申请人： Jennifer Lynne Reed ,  William Dall'Acqua ,  Jacques Van Snick ,  Jean-Christophe Renauld ,  Francoise Cormont ,  Catherine Uyttenhove

发明人： Jennifer Lynne Reed ,  William Dall'Acqua ,  Jacques Van Snick ,  Jean-Christophe Renauld ,  Francoise Cormont ,  Catherine Uyttenhove

IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P43/00

CPC分类号： C07K16/244 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76

摘要： The application describes neutralizing chimeric and humanized anti-human IL-9 antibodies, and the use thereof to identify neutralizing epitopes on human IL-9 and as medicaments to prevent and treat asthma, bronchial hyperresponsiveness, atopic allergy, and other related disorders. Particularly disclosed are recombinant antibodies derived from three murine anti-human IL-9 antibodies identified infra as MH9A3, MH9D1, and MH9L1.

摘要翻译： 该应用描述了中和嵌合和人源化抗人IL-9抗体，以及其用于鉴定人IL-9上的中和表位以及用作预防和治疗哮喘，支气管高反应性，特应性变态反应和其它相关疾病的药物。 特别公开的是衍生自以下鉴定的三种鼠抗人IL-9抗体作为MH9A3，MH9D1和MH9L1的重组抗体。