公开(公告)号：US20120289863A1

公开(公告)日：2012-11-15

申请号：US13541641

申请日：2012-07-03

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/00 ,  G01N33/538

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

公开(公告)号：US08611992B2

公开(公告)日：2013-12-17

申请号：US13541641

申请日：2012-07-03

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/00

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

公开(公告)号：US08326412B2

公开(公告)日：2012-12-04

申请号：US13249521

申请日：2011-09-30

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/05

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以便确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。

公开(公告)号：US20120083711A1

公开(公告)日：2012-04-05

申请号：US13249521

申请日：2011-09-30

申请人： Andrew S. Goldstein ,  Frank Bellizzi

发明人： Andrew S. Goldstein ,  Frank Bellizzi

IPC分类号： A61B5/00

CPC分类号： A61B5/4875 ,  A61B5/4277 ,  A61B5/4848 ,  A61B5/682 ,  A61B10/0051 ,  A61B2562/0209 ,  A61B2562/029 ,  G01N33/48707

摘要： Timed sensing of collection of saliva in a liquid collection element of predetermined volumetric capacity may be used to determine salivary secretion rate, as may be indicative of state of euhydration or dehydration. Sensing of salivary flow rate may be further augmented by sensing concentration of at least one analyte in saliva (e.g., with an immunochromatographic assay performed in a lateral flow device) in order to determine a state of euhydration or dehydration. Production of saliva may be stimulated, and collected saliva may be analyzed to generate an analyte detection signal that indicative of presence and/or correlative of concentration of at least one analyte in the collected saliva to sense a state of euhydration or dehydration.

摘要翻译： 在预定体积容量的液体收集元件中收集唾液的定时感测可以用于确定唾液分泌速率，这可以指示脱水或脱水的状态。 通过感测唾液中至少一种分析物的浓度（例如，通过在侧流装置中进行的免疫色谱测定）来进一步增强唾液流速的感测，以便确定脱水或脱水的状态。 可以刺激唾液的产生，并且可以分析收集的唾液以产生指示所收集的唾液中至少一种分析物的浓度的存在和/或相关性的分析物检测信号，以感测脱水或脱水的状态。