公开(公告)号：US5550060A

公开(公告)日：1996-08-27

申请号：US237095

申请日：1994-05-03

申请人： Alexander Saunders ,  Frank W. Summerfield ,  Michael A. Zarowitz

发明人： Alexander Saunders ,  Frank W. Summerfield ,  Michael A. Zarowitz

IPC分类号： A61K35/18 ,  C12N15/82 ,  B01D21/26

CPC分类号： A61K35/18 ,  C12N15/8289 ,  Y10T436/115831

摘要： Methods and apparatus for separating red blood cells by density are described. Older red blood cells are more dense than younger ones. Certain changes in the physiology are recorded in changes in hemoglobin or the red blood cells. By assaying different aged red blood cells, one can determine the historical physiological changes over a period of many weeks. Improved separation of red blood cells is accomplished by using rigid capillary tubes having an inner surface which augments the density equilibrium of red blood cells and/or incrementally increasing the centrifugation forces, as well as by chemically treating red blood cells to improve their deformability.

摘要翻译： 描述了通过密度分离红细胞的方法和装置。 较老的红细胞比较年轻的血细胞更密集。 生理学中的某些变化记录在血红蛋白或红细胞的变化中。 通过分析不同的老年红细胞，可以确定多周的历史生理变化。 通过使用具有增加红细胞的密度平衡的内表面和/或逐渐增加离心力的内表面的刚性毛细管以及通过化学处理红细胞以改善其变形能力来实现红细胞分离的改进。