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公开(公告)号:US20070005255A1
公开(公告)日:2007-01-04
申请号:US11005566
申请日:2004-12-07
申请人: Miriam Tendler , Richard Garrat , Naftale Katz , Andrew Simpson , Frank de Barrientos , Monica Vilar , Marilia Almeida
发明人: Miriam Tendler , Richard Garrat , Naftale Katz , Andrew Simpson , Frank de Barrientos , Monica Vilar , Marilia Almeida
CPC分类号: A61K39/0003 , A61K39/00 , C07K14/4354 , C07K14/43559 , C07K2319/00 , G01N33/6893 , Y02A50/423
摘要: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.
摘要翻译: 本发明涉及具有与曼氏男性(Sm14)或相关FABP(脂肪酸结合蛋白)的14kDa蛋白质的特定部分的特定部分的氨基酸序列具有一个或多个共有和/或相似氨基酸序列的肽片段, 所述肽片段用作分子的连续或不连续表位区域或模拟其生物学活性。 更具体地,本发明涉及使用所述肽片段构建活性肽片段,肽片段,免疫原性组合物和诊断试剂盒的方法。