公开(公告)号：US20120309787A1

公开(公告)日：2012-12-06

申请号：US13570938

申请日：2012-08-09

Applicant: SIEW YEEN CHAI ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Frederick A.O. Mendelsohn ,  Keith Geoffrey Watson

Inventor： SIEW YEEN CHAI ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Frederick A.O. Mendelsohn ,  Keith Geoffrey Watson

IPC: A61K31/4709 ,  A61P25/00

CPC classification number: C07D405/04

Abstract: The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions.

Abstract translation: 本发明涉及胰岛素调节氨基肽酶抑制剂（IRAP）及其抑制方法，以及包含所述抑制剂的组合物。 特别地，本发明的抑制剂可用于治疗应用，包括增强记忆和学习功能。

公开(公告)号：US20110021563A1

公开(公告)日：2011-01-27

申请号：US12743225

申请日：2008-11-18

Applicant: Siew Yeen Chai ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Frederick A.O. Mendelsohn ,  Keith Geoffrey Watson

Inventor： Siew Yeen Chai ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Frederick A.O. Mendelsohn ,  Keith Geoffrey Watson

IPC: C07D407/04 ,  A61K31/4725 ,  A61K31/4433 ,  C12Q1/37

CPC classification number: C07D405/04

Abstract: The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions.

Abstract translation: 本发明涉及胰岛素调节氨基肽酶抑制剂（IRAP）及其抑制方法，以及包含所述抑制剂的组合物。 特别地，本发明的抑制剂可用于治疗应用，包括增强记忆和学习功能。

公开(公告)号：US20080194636A1

公开(公告)日：2008-08-14

申请号：US11662392

申请日：2005-09-09

Applicant: Siew Yeen Chai ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Craig J. Morton ,  Hooi Ling Ng ,  Siying Ye ,  Frederick A.O. Mendelsohn

Inventor： Siew Yeen Chai ,  Michael William Parker ,  Anthony Lloyd Albiston ,  Craig J. Morton ,  Hooi Ling Ng ,  Siying Ye ,  Frederick A.O. Mendelsohn

IPC: A61K31/4433 ,  C12N9/99 ,  A61K31/352 ,  C12Q1/37 ,  A61P25/00

CPC classification number: C12N9/48 ,  A61K31/352 ,  A61K31/4433 ,  G01N2500/02

Abstract: The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the inhibitors of the present invention may be useful in therapeutic applications including enhancing memory and learning functions, regulating cellular glucose uptake and homeostasis, inducing labour and lactation, and other disorders or conditions wherein excessive or undesirable IRAP activity is implicated.

Abstract translation: 本发明涉及胰岛素调节氨基肽酶抑制剂（IRAP）及其抑制方法，以及包含所述抑制剂的组合物。 特别地，本发明的抑制剂可用于治疗应用，包括增强记忆和学习功能，调节细胞葡萄糖摄取和体内平衡，诱导劳动和哺乳期以及涉及过度或不期望的IRAP活性的其它病症或病症。