公开(公告)号：US5523317A

公开(公告)日：1996-06-04

申请号：US188446

申请日：1994-01-26

申请人： Mitsuo Masaki ,  Fumiyo Hara ,  Toshiro Kamishiro

发明人： Mitsuo Masaki ,  Fumiyo Hara ,  Toshiro Kamishiro

IPC分类号： A61K31/415 ,  A61K31/47 ,  A01N43/50

CPC分类号： A61K31/47 ,  A61K31/415

摘要： Disclosed is a method of reducing blood pressure which comprises administering to a patient an imidazole derivative of the formula: ##STR1## wherein: each of R.sup.1 and R.sup.2 is hydrogen, substituted or unsubstituted alkyl, alkoxyalkyl, cycloalkyl, aryl, aralkyl, or R.sup.1 and R.sup.2 are combined to form hetero ring; each of R.sup.3, R.sup.4, R.sup.5 and R.sup.6 is hydrogen, halogen, substituted or unsubstituted alkoxy, substituted or unsubstituted alkyl, aryl, aryloxy, alkoxycarbonyl, nitro, amino, acyl, or R.sup.3 is combined with R.sup.2 to form heteroring; R.sup.7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted arylcarbonyl, or S-containing heteroring; each of R.sup.8 and R.sup.9 is hydrogen, halogen, substituted or unsubstituted alkoxy, unsubstituted or substituted alkyl, alkoxycarbonyl, aralkyl, nitro, amino, acyl, substituted or unsubstituted aryl, or R.sup.8 and R.sup.9 are combined to from alkylene; and n is 0 or 1.

摘要翻译： 公开了降低血压的方法，其包括向患者施用下式的咪唑衍生物：其中：R 1和R 2各自为氢，取代或未取代的烷基，烷氧基烷基，环烷基，芳基，芳烷基， 或R 1和R 2结合形成杂环; R 3，R 4，R 5和R 6中的每一个为氢，卤素，取代或未取代的烷氧基，取代或未取代的烷基，芳基，芳氧基，烷氧基羰基，硝基，氨基，酰基或R3与R 2结合形成杂环; R 7是氢，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的芳基羰基或含S的杂环; R8和R9各自为氢，卤素，取代或未取代的烷氧基，未取代或取代的烷基，烷氧基羰基，芳烷基，硝基，氨基，酰基，取代或未取代的芳基，或R8和R9与亚烷基结合; n为0或1。