公开(公告)号：US5672742A

公开(公告)日：1997-09-30

申请号：US615557

申请日：1996-03-12

申请人： Takehiro Sonoi ,  Futoshi Masaki, deceased ,  Toshio Kubota

发明人： Takehiro Sonoi ,  Futoshi Masaki, deceased ,  Toshio Kubota

IPC分类号： C07C51/09 ,  C07C51/093 ,  C07C51/377 ,  C07C51/38 ,  C07C57/52 ,  C07C57/58 ,  C07C53/34

CPC分类号： C07C57/52 ,  C07C51/093

摘要： .alpha.-(trifluoromethyl)arylacetic acid for use as raw materials for medicines, agricultural chemicals, liquid crystals etc. or reagents for determining an optical purity is readily obtained through very simple reaction steps, i.e. by reacting a perfluoro(2-methyl-1,2-epoxypropyl)ether compound obtainable by ozone, oxidation of a heptafluoroisobutenyl ether compound with an aromatic compound ArH to afford an .alpha.,.alpha.-bis(trifluoromethyl)arylacetic acid ester, followed by decarboxylation and hydrolysis of the resulting ester compound.

摘要翻译： 用作药物，农药，液晶等原料的α-（（三氟甲基）芳基乙酸或用于测定光学纯度的试剂通过非常简单的反应步骤，即通过使全氟（2-甲基-1- 通过臭氧获得的2-环氧丙基）醚化合物，用芳族化合物ArH氧化七氟异丁烯基醚化合物，得到α，α-双（三氟甲基）芳基乙酸酯，然后将所得酯化合物脱羧和水解。