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公开(公告)号:US06258596B1
公开(公告)日:2001-07-10
申请号:US08952796
申请日:1998-06-05
申请人: Patrick Benoit , Eric Bruckert , Patrice Denefle , Nicolas Duverger , Jean-Charles Fruchart , Gérald Luc , Gérard Turpin , Gerd Assmann , Harald Funke
发明人: Patrick Benoit , Eric Bruckert , Patrice Denefle , Nicolas Duverger , Jean-Charles Fruchart , Gérald Luc , Gérard Turpin , Gerd Assmann , Harald Funke
IPC分类号: C07K1600
CPC分类号: C07K14/775 , A61K38/00 , A61K48/00 , C12N2799/021 , C12N2799/022
摘要: The present invention relates to variants of the human apolipoproteine A-I comprising a cystein in position 151, the corresponding nucleic acids and the vectors containing them. It also relates to pharmaceutical compositions comprising said elements and their utilization, particularly in genic therapy.
摘要翻译: 本发明涉及包含151位半胱氨酸的人载脂蛋白A-1的变体,相应的核酸和含有它们的载体。 它还涉及包含所述元件及其利用的药物组合物,特别是在基因治疗中。