公开(公告)号：US20240170146A1

公开(公告)日：2024-05-23

申请号：US18213070

申请日：2023-06-22

申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  GEORGIA TECH RESEARCH CORPORATIONS ,  EMORY UNIVERSITY

发明人： Sankaraleengam Alagapan ,  Christopher Rozell ,  Helen Mayberg ,  Vineet Tiruvadi ,  Allison Waters ,  Patricio Riva-Posse ,  Stephen Heisig ,  Robert Butera ,  Ki Sueng Choi ,  Andrea Crowell

IPC分类号： G16H50/20 ,  G16H10/60 ,  G16H50/50

CPC分类号： G16H50/20 ,  G16H10/60 ,  G16H50/50

摘要： Methods and systems are described for providing deep brain stimulation (DBS) of the subcallosal cingulate region (SCC) to provide symptom relief in patients with treatment-resistant depression (TRD). The DBS devices may enable chronic electrophysiology recording to deliver SCC DBS therapy. One or more machine-learning models may identify SCC LFP changes that indicate the patient's current clinical state. The clinical state is distinct from acute transient stimulation effects, is sensitive to DBS stimulation adjustments, and accurately captures individual differences in recovery trajectory.