公开(公告)号：US07632859B2

公开(公告)日：2009-12-15

申请号：US10713424

申请日：2003-11-17

申请人： Gai Ling Li ,  Johanna Aaltje Bouwstra ,  Hans-Michael Wolff ,  Akhmad Karis Nugroho

发明人： Gai Ling Li ,  Johanna Aaltje Bouwstra ,  Hans-Michael Wolff ,  Akhmad Karis Nugroho

IPC分类号： A01N43/06 ,  A61K31/38 ,  A61N1/30

CPC分类号： A61K31/381 ,  A61K9/0009

摘要： By using a composition comprising rotigotine and at least one chloride salt in a concentration of 1 to 140 mmol/l, the composition having a pH of 4 to 6.5 in a iontophoretic device for the treatment of Parkinson's disease, it became possible to obtain a rotigotine flux across the human stratum corneum which was higher than the one previously obtained with conventional passive diffusion systems.

摘要翻译： 通过使用包含罗替戈汀和至少一种浓度为1至140mmol / l的氯化物的组合物，该组合物在用于治疗帕金森病的离子电渗疗法中具有4至6.5的pH值，可以获得罗替戈汀 通量超过人类角质层，其高于先前用常规被动扩散系统获得的角质层。