公开(公告)号：US09095515B2

公开(公告)日：2015-08-04

申请号：US12723808

申请日：2010-03-15

Applicant: Umit Cifter ,  Levent Oner ,  Ali Turkyilmaz ,  Ibrahim Murat Uzer ,  Gaye Ramazanoglu

Inventor： Umit Cifter ,  Levent Oner ,  Ali Turkyilmaz ,  Ibrahim Murat Uzer ,  Gaye Ramazanoglu

IPC: A61K31/397 ,  A61K9/20

CPC classification number: A61K9/2018 ,  A61K31/397

Abstract: This invention is a novel pharmaceutical composition of ezetimibe or a pharmaceutically acceptable salt thereof comprising one or more pharmaceutically acceptable excipients having high bioavailability with improved solubility and dissolution rate which is stable throughout the shelflife, methods for their preparation, and methods for treatment using the same.

Abstract translation: 本发明是依泽替米贝或其药学上可接受的盐的新型药物组合物，其包含一种或多种药学上可接受的赋形剂，其具有高的生物利用度，其改进的溶解度和溶解速率在整个保质期内是稳定的，其制备方法和使用其的治疗方法 。

公开(公告)号：US20110305757A1

公开(公告)日：2011-12-15

申请号：US13159049

申请日：2011-06-13

Applicant: Umit Cifter ,  Ali Turkyilmaz ,  Onur Mutlu ,  Gaye Ramazanoglu

Inventor： Umit Cifter ,  Ali Turkyilmaz ,  Onur Mutlu ,  Gaye Ramazanoglu

IPC: A61K9/28 ,  A61K31/549 ,  B29C67/24 ,  A61P9/12 ,  B29C67/00 ,  A61K31/4245 ,  A61K9/24

CPC classification number: A61K31/54 ,  A61K9/2054 ,  A61K31/4245 ,  A61K31/549 ,  A61K31/635 ,  A61K2300/00

Abstract: A pharmaceutical composition including a compound of Formula I (Compound I) or pharmaceutically acceptable salts thereof and one or more diuretics as effective components, wherein said one or more diuretics are selected from thiazide derivatives. Methods for preparing the pharmaceutical compound including Compound I and thiazide derivatives and its use for preventing or treating hypertension in mammals, particularly in humans.

Abstract translation: 一种药物组合物，其包含式I化合物（化合物I）或其药学上可接受的盐和一种或多种利尿剂作为有效成分，其中所述一种或多种利尿剂选自噻嗪类衍生物。 制备包括化合物I和噻嗪类衍生物的药物化合物的方法及其在哺乳动物，特别是人类中预防或治疗高血压的用途。

公开(公告)号：US20100234342A1

公开(公告)日：2010-09-16

申请号：US12723808

申请日：2010-03-15

Applicant: Umit Cifter ,  Levent Oner ,  Ali Turkyilmaz ,  Ibrahim Murat Uzer ,  Gaye Ramazanoglu

Inventor： Umit Cifter ,  Levent Oner ,  Ali Turkyilmaz ,  Ibrahim Murat Uzer ,  Gaye Ramazanoglu

IPC: A61K31/397

CPC classification number: A61K9/2018 ,  A61K31/397

Abstract: This invention is a novel pharmaceutical composition of ezetimibe or a pharmaceutically acceptable salt thereof comprising one or more pharmaceutically acceptable excipients having high bioavailability with improved solubility and dissolution rate which is stable throughout the shelflife, methods for their preparation, and methods for treatment using the same.

Abstract translation: 本发明是依泽替米贝或其药学上可接受的盐的新型药物组合物，其包含一种或多种药学上可接受的赋形剂，其具有高的生物利用度，其改进的溶解度和溶解速率在整个保质期内是稳定的，其制备方法和使用其的治疗方法 。