公开(公告)号：US20050267136A1

公开(公告)日：2005-12-01

申请号：US11090148

申请日：2005-03-28

申请人： Eric Brown ,  Xiaoming Li ,  Gerard Wright ,  Jonathan Cechetto ,  Michela Juran ,  Rebecca Hartlen ,  Ranjana Pathania

发明人： Eric Brown ,  Xiaoming Li ,  Gerard Wright ,  Jonathan Cechetto ,  Michela Juran ,  Rebecca Hartlen ,  Ranjana Pathania

IPC分类号： A61K31/17 ,  A61K31/517 ,  A61K31/53 ,  A61P31/04

CPC分类号： A61K31/53 ,  A61K31/17 ,  A61K31/517 ,  Y02A50/473 ,  Y02A50/481

摘要： A novel screening assay for identifying therapeutic agents and their cellular targets is described. The assay is useful in developing new antibacterial, antifungal, antiparasitic and anti cancer therapeutics. New inhibitors of dihydrofolate reductase (DHFR) have been identified and their cellular target confirmed using the assay of the present invention. Methods of treating diseases that benefit from an inhibition of DHFR are also described.

摘要翻译： 描述了用于鉴定治疗剂及其细胞靶标的新型筛选试验。 该测定法可用于开发新的抗菌，抗真菌，抗寄生虫和抗癌药物。 已经鉴定了二氢叶酸还原酶（DHFR）的新抑制剂，并且使用本发明的测定确认了它们的细胞靶。 还描述了治疗受到抑制DHFR的疾病的方法。

公开(公告)号：US20050272646A1

公开(公告)日：2005-12-08

申请号：US11108558

申请日：2005-04-18

申请人： Kalinka Koteva ,  Tariq Mukhtar ,  Gerard Wright

发明人： Kalinka Koteva ,  Tariq Mukhtar ,  Gerard Wright

IPC分类号： A61K38/00 ,  A61K38/12 ,  C07K7/54 ,  C07K7/64

CPC分类号： C07K7/64 ,  A61K38/00 ,  C07K7/54 ,  Y02A50/473

摘要： Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.

摘要翻译： 公开了一种环状肽抗生素，其中酶敏键被酶抗性键取代。

公开(公告)号：US4850868A

公开(公告)日：1989-07-25

申请号：US72471

申请日：1987-07-13

申请人： Gerard Wright ,  George E. Warrin ,  Richard H. Paschke

发明人： Gerard Wright ,  George E. Warrin ,  Richard H. Paschke

IPC分类号： A61C1/08 ,  A61C3/025 ,  A61C17/02

CPC分类号： A61C3/025 ,  A61C17/0202

摘要： The apparatus comprises a tubular member that is adapted to be attached to the working end of a dental handpiece and is used to contain and direct material dispensed from the handpiece in order to reduce the amount of airborne particles emitted into the atmosphere by the handpiece and to accurately direct the dispensed material to the desired area. The apparatus is adapted to provide a reference point for the practitioner in establishing the optimum working distance of the handpiece from a particular working area in the mouth when the handpiece is used. An improved dental handpiece using the apparatus of the invention and a method of using the apparatus are also provided.

公开(公告)号：US07169756B2

公开(公告)日：2007-01-30

申请号：US11108558

申请日：2005-04-18

申请人： Kalinka Koteva ,  Tariq Mukhtar ,  Gerard Wright

发明人： Kalinka Koteva ,  Tariq Mukhtar ,  Gerard Wright

IPC分类号： A61K38/12

CPC分类号： C07K7/64 ,  A61K38/00 ,  C07K7/54 ,  Y02A50/473

摘要： Disclosed is a cyclic peptide antibiotic in which an enzyme-sensitive bond is replaced by an enzyme-resistant bond.

摘要翻译： 公开了一种环状肽抗生素，其中酶敏键被酶抗性键取代。