公开(公告)号：US08003738B2

公开(公告)日：2011-08-23

申请号：US11293246

申请日：2005-12-05

申请人： Nathalie Bouillo ,  Gerhard Röβler

发明人： Nathalie Bouillo ,  Gerhard Röβler

IPC分类号： C08F2/06 ,  C08F6/10 ,  C08F26/10 ,  C08F26/06

CPC分类号： A61K47/32 ,  A61K8/04 ,  A61K8/8182 ,  A61Q19/00 ,  C08F2/00 ,  C08F2/001 ,  C08F2/16 ,  C08F220/18 ,  C08F226/10

摘要： The present invention relates to a method of producing aqueous secondary dispersions of water-insoluble copolymers by free-radical solution polymerization of ethylenically unsaturated monomers M comprising: i) at least one hydrophobic, monoethylenically unsaturated monomer M1 with a solubility in water of not more than 30 g/l at 25° C. and 1 bar and ii) at least one hydrophilic, monoethylenically unsaturated, nonionic comonomer M2 with a solubility in water of at least 80 g/l at 25° C. and 1 bar, in an organic, water-miscible solvent or a mixture of water with an organic, water-miscible solvent as polymerization medium and subsequent replacement of the organic solvent by water in which, toward the end of the polymerization, some of the monomers M are added in the form of a monomer composition M′ which comprises essentially only monomers M2 as monomers. The present invention also relates to the aqueous polymer dispersions obtainable by the method according to the invention and to their use, particularly in pharmacy and cosmetics.

摘要翻译： 本发明涉及通过烯键式不饱和单体M的自由基溶液聚合制备水不溶性共聚物的水分二次分散体的方法，其包括：i）至少一种在水中的溶解度不大于的疏水性单烯属不饱和单体M1 在25℃和1巴下30g / l，和ii）在有机物中在25℃和1巴下具有至少80g / l的水溶性的至少一种亲水性，单烯属不饱和的非离子共聚单体M2 ，水混溶性溶剂或水与有机，水混溶性溶剂的混合物作为聚合介质，随后用水代替有机溶剂，其中在聚合结束时，以形式加入一些单体M 的单体组合物M'，其基本上仅包含单体M2作为单体。 本发明还涉及通过根据本发明的方法获得的水性聚合物分散体及其用途，特别是在药学和化妆品中。