公开(公告)号：US11672821B2

公开(公告)日：2023-06-13

申请号：US16668048

申请日：2019-10-30

申请人： Gerolymatos International S.A.

发明人： Konstantinos Alevizopoulos

IPC分类号： A61K31/737 ,  A61K36/03 ,  A61K31/164 ,  A61K9/00 ,  A61K9/08 ,  A61K31/197 ,  A61K36/04 ,  A61K36/53 ,  A61K45/06 ,  A61K35/747 ,  A61K35/748 ,  A61K47/02

CPC分类号： A61K31/737 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/164 ,  A61K31/197 ,  A61K35/747 ,  A61K35/748 ,  A61K36/03 ,  A61K36/04 ,  A61K36/53 ,  A61K45/06 ,  A61K47/02 ,  A61K31/737 ,  A61K2300/00 ,  A61K31/164 ,  A61K2300/00 ,  A61K31/197 ,  A61K2300/00

摘要： Disclosed herein are ionic aqueous compositions useful as nasal passage washes to aid in the resorption of edema of the respiratory mucosa, e.g., the nasal mucosa, for the treatment of respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis, sinusitis, allergic rhinitis and nasal polyps. The composition includes an ionic aqueous solution and algae-derived constituents, such as branched, sulfated polysaccharides having an average molecular weight greater than 4 kDa and comprising L-fucose and sulfate ester groups or extracts from brown algae. Also disclosed are methods and pharmaceutical compositions for treating respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis.

公开(公告)号：US20170000817A1

公开(公告)日：2017-01-05

申请号：US15100187

申请日：2014-11-28

申请人： Gerolymatos International S.A.

发明人： Konstantinos Alevizopoulos

IPC分类号： A61K31/737 ,  A61K35/748 ,  A61K9/08 ,  A61K31/164 ,  A61K9/00 ,  A61K36/03 ,  A61K47/02

CPC分类号： A61K31/737 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/164 ,  A61K31/197 ,  A61K35/747 ,  A61K35/748 ,  A61K36/03 ,  A61K36/04 ,  A61K36/53 ,  A61K45/06 ,  A61K47/02 ,  A61K2300/00

摘要： Disclosed herein are ionic aqueous compositions useful as nasal passage washes to aid in the resorption of edema of the respiratory mucosa, e.g., the nasal mucosa, for the treatment of respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis, sinusitis, allergic rhinitis and nasal polyps. The composition includes an ionic aqueous solution and algae-derived constituents, such as branched, sulfated polysaccharides having an average molecular weight greater than 4 kDa and comprising L-fucose and sulfate ester groups or extracts from brown algae. Also disclosed are methods and pharmaceutical compositions for treating respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis.

摘要翻译： 本文公开了用作鼻通道洗涤物的离子水性组合物，以帮助吸入呼吸道粘膜（例如鼻粘膜）的水肿，用于治疗呼吸道和/或呼吸道粘膜相关病症，包括例如慢性鼻鼻窦炎 ，鼻窦炎，过敏性鼻炎和鼻息肉。 组合物包括离子水溶液和藻类衍生的成分，例如平均分子量大于4kDa的分支的硫酸化多糖，并且包含L-岩藻糖和硫酸酯基团或来自棕藻的提取物。 还公开了用于治疗呼吸道和/或呼吸道粘膜相关病症的方法和药物组合物，包括例如慢性鼻鼻窦炎。

公开(公告)号：US20200061100A1

公开(公告)日：2020-02-27

申请号：US16668048

申请日：2019-10-30

申请人： Gerolymatos International S.A.

发明人： Konstantinos Alevizopoulos

IPC分类号： A61K31/737 ,  A61K36/03 ,  A61K31/164 ,  A61K9/00 ,  A61K9/08 ,  A61K35/748 ,  A61K47/02 ,  A61K31/197 ,  A61K36/04 ,  A61K36/53 ,  A61K45/06 ,  A61K35/747

摘要： Disclosed herein are ionic aqueous compositions useful as nasal passage washes to aid in the resorption of edema of the respiratory mucosa, e.g., the nasal mucosa, for the treatment of respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis, sinusitis, allergic rhinitis and nasal polyps. The composition includes an ionic aqueous solution and algae-derived constituents, such as branched, sulfated polysaccharides having an average molecular weight greater than 4 kDa and comprising L-fucose and sulfate ester groups or extracts from brown algae. Also disclosed are methods and pharmaceutical compositions for treating respiratory tract and/or respiratory mucosal-related conditions, including, e.g., chronic rhinosinusitis.