公开(公告)号：US07485656B2

公开(公告)日：2009-02-03

申请号：US10467244

申请日：2002-02-07

申请人： Sang-Lin Kim ,  Hyun-Kwang Tan ,  Jun-Sik Kim ,  Ho-Beom Lee ,  Geun-Hong Min ,  Hae-Won Ryou

发明人： Sang-Lin Kim ,  Hyun-Kwang Tan ,  Jun-Sik Kim ,  Ho-Beom Lee ,  Geun-Hong Min ,  Hae-Won Ryou

IPC分类号： A61K31/4196 ,  A61K31/41 ,  A61K9/06

CPC分类号： A61K9/0014 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26

摘要： An antibacterial composition for external application, particularly, a remedial formulation for external use containing fluconazole is disclosed. The formulation comprises a base material, 0.1-5.0 percent by weight of fluconazole and 1.0-40.0 percent by weight of any one compound selected from a group consisting of fatty acid, fatty alcohol, higher fatty acid ester and lower alcohol based on weight of the base material. The composition according to the present invention has various advantages of a favorable absorption into a system through the skin of a human body and delivery of active material into horny layer of the skin, a reduced skin stimulation and an excellent stability. Therefore, the composition is efficiently useable in a medical treatment application for dermatomycosis-related infectious diseases including tinea pedis, tinea corporis, tinea cruris, tinea versicolor and/or candidiasis and the like.

摘要翻译： 公开了一种用于外用的抗菌组合物，特别是含有氟康唑的外用补救制剂。 该制剂包含基础材料，0.1-5.0重量％的氟康唑和1.0-40.0重量％的任何一种选自脂肪酸，脂肪醇，高级脂肪酸酯和低级醇的化合物，基于 基材。 根据本发明的组合物具有通过人体皮肤对体系的有利吸收以及将活性物质递送到皮肤角质层，减少的皮肤刺激和优异的稳定性的各种优点。 因此，该组合物可有效地用于涉及皮肤真菌病相关感染性疾病的医疗用途，包括足癣，癣，癣，癣斑和/或念珠菌病等。