公开(公告)号：US20200164225A1

公开(公告)日：2020-05-28

申请号：US16324060

申请日：2017-08-03

申请人： Hao H. ZHANG ,  Gokhan KIRLIK ,  Warren D. D'SOUZA ,  Byong Young YI

发明人： Hao H. ZHANG ,  Gokhan KIRLIK ,  Warren D. D'SOUZA ,  Byong Young YI

IPC分类号： A61N5/10

摘要： A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes determining voxels in a reference frame of a radiation source that rotates at an angular rate of change and emits a beam at a plurality of angles. The beam has a beam intensity and a cross sectional shape based on an aperture of a collimator at each angle. The method includes determining an initial aperture value at each angle and minimizing a single objective function subject to a constraint on an aperture rate of change to determine an aperture and beam intensity at each angle. The method also includes delivering a beam of radiation with controlled intensity at each angle based on the beam intensity and aperture and turning the beam of radiation off at an intervening angle not included in the plurality of angles.

公开(公告)号：US10828511B2

公开(公告)日：2020-11-10

申请号：US16324060

申请日：2017-08-03

申请人： Hao H. Zhang ,  Gokhan Kirlik ,  Warren D. D'Souza ,  Byong Young Yi

发明人： Hao H. Zhang ,  Gokhan Kirlik ,  Warren D. D'Souza ,  Byong Young Yi

IPC分类号： A61N5/10

摘要： A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes determining voxels in a reference frame of a radiation source that rotates at an angular rate of change and emits a beam at a plurality of angles. The beam has a beam intensity and a cross sectional shape based on an aperture of a collimator at each angle. The method includes determining an initial aperture value at each angle and minimizing a single objective function subject to a constraint on an aperture rate of change to determine an aperture and beam intensity at each angle. The method also includes delivering a beam of radiation with controlled intensity at each angle based on the beam intensity and aperture and turning the beam of radiation off at an intervening angle not included in the plurality of angles.

公开(公告)号：US20170246477A1

公开(公告)日：2017-08-31

申请号：US15445073

申请日：2017-02-28

申请人： Hao H. Zhang ,  Gokhan Kirlik ,  Warren D. D'Souza

发明人： Hao H. Zhang ,  Gokhan Kirlik ,  Warren D. D'Souza

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/1039 ,  A61N5/1047

摘要： A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes defining a single objective function based on a plurality of objective functions that are each associated with a plurality of tissue types within a subject, upper and lower bounds for each objective function and a plurality of apertures. The method also includes determining a radiation dose delivered to voxels of each tissue type based on minimizing the single objective function based on the plurality of apertures with initial values at each angle. The method also includes delivering a beam of radiation with controlled intensity and beam cross-sectional shape at each angle based on the plurality of apertures.